非生物型人工肝技术的优化与生物型人工肝研究进展

周莉; 杨颜榕; 陈煜

doi:10.12449/JCH240204

非生物型人工肝技术的优化与生物型人工肝研究进展

DOI: 10.12449/JCH240204

首都医科大学附属北京佑安医院肝病中心四科（疑难肝病及人工肝中心），肝衰竭与人工肝治疗研究北京市重点实验室，北京 100069

基金项目:

国家重点研发计划项目 (2022YFC2304400);

北京市医院管理中心“登峰”人才培养计划 (DFL20221501);

高层次公共卫生技术人才培养计划 (2022-2-012);

北京市科技新星计划 (20220484201)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：周莉、杨颜榕负责查阅和分析资料，撰写论文；陈煜负责选题，拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
陈煜， chybeyond1071@ccmu.edu.cn （ORICD： 0000-0003-1906-7486）

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- 被引次数: 0
出版历程
- 收稿日期: 2023-11-13
- 录用日期: 2023-12-15
- 出版日期: 2024-02-19

Optimization of non-bioartificial liver technology and research advances in biological artificial liver

Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research，Forth Department of Liver Disease Center/Difficult and Complicated Liver Diseases and Artificial Liver Center，Beijing YouAn Hospital，Capital Medial University，Beijing 100069，China

Research funding:

National Key Research and Development Program of China (2022YFC2304400);

Beijing Hospitals Authority’s Ascent Plan (DFL20221501);

Construction Project of High-level Technology Talents in Public Health (2022-2-012);

Beijing Nova Program (20220484201)

More Information

Corresponding author: CHEN Yu， chybeyond1071@ccmu.edu.cn （ORICD： 0000-0003-1906-7486）

摘要

摘要: 肝衰竭是临床常见综合征，进展快速，预后不良。目前其内科治疗方法仍有限，人工肝治疗是一种有效的治疗方法。非生物型人工肝技术在临床上广泛应用，其具体的启动时机、模式的选择、参数的设置需要临床医生根据疾病的病理生理机制及动态演变过程，结合患者具体情况决定。与非生物型人工肝相比，生物型人工肝能更好地模拟肝细胞的生物学功能，目前其核心技术已取得实质性的进展，相关临床研究也在积极进行，在未来有广阔的发展前景。本文就非生物型人工肝技术的优化及生物型人工肝相关进展进行总结与探讨，以期为人工肝技术的临床应用与研究提供参考。
- 肝，人工 /
- 肝功能衰竭 /
- 治疗学
Abstract: Liver failure is a common clinical syndrome with rapid progression and poor prognosis. Currently， there are still limited internal medical treatment methods for liver failure， and artificial liver support therapy is an effective treatment method. Non-bioartificial liver technology is widely used in clinical practice， and clinicians should determine the starting time， mode， and specific parameters of treatment according to the pathophysiological mechanism and dynamic evolution process of the disease， as well as the specific conditions of patients. Compared with non-bioartificial liver， biological artificial liver can better simulate the biological function of liver cells. At present， substantial progress has been made in its core technology， and related clinical studies are being conducted actively， suggesting a vast potential for future development. This article summarizes and discusses the optimization of non-bioartificial liver technology and the advances in biological artificial liver， in order to provide a reference for the clinical application and research of artificial liver technology.
- Liver， Artificial /
- Liver Failure /
- Therapeutics

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参考文献(43)

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