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胰管高压导致高脂血症性急性胰腺炎的发病机制

冯佳晨 张平

引用本文:
Citation:

胰管高压导致高脂血症性急性胰腺炎的发病机制

DOI: 10.12449/JCH240134
利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:张平负责课题设计;张平、冯佳晨进行查阅文献并起草论文,论文撰写及修改、校阅论文。
详细信息
    通信作者:

    张平, z_ping@jlu.edu.cn (ORCID: 0000-0003-4944-2937)

The pathogenesis of hyperlipidemic acute pancreatitis caused by pancreatic duct hypertension

More Information
    Corresponding author: ZHANG Ping, z_ping@jlu.edu.cn (ORCID: 0000-0003-4944-2937)
  • 摘要: 高脂血症性急性胰腺炎与其他病因的急性胰腺炎相比,重症率更高,预后更难预测,发病机制复杂且不清晰。目前已知的发病机制可能与血清游离脂肪酸升高有关,但降低血脂的治疗方案并未降低本病的发病率。近期,胰管高压是急性胰腺炎重要的发病机制被进一步证实,而最新研究进展表明高脂血症可通过引起胰管增生、形成胆胰管汇合部蛋白栓、损伤胰管的分泌功能来导致胰管堵塞,胰管堵塞又可引起胰管高压。本文综述了高脂血症在导致胰管堵塞方面的最新研究和进展,并强调胰管高压是高脂血症性急性胰腺炎重要的发病机制之一,这将为研究高脂血症性急性胰腺炎的发病机制提供新的思路。

     

  • 图  1  正常胆胰管合流-V型

    Figure  1.  Normal bile pancreatic duct confluence -V type

    图  2  正常胆胰管合流-小Y型

    Figure  2.  Normal biliary pancreatic duct confluence - small Y pattern

    图  3  异常胆胰管合流B-P型

    Figure  3.  Abnormal biliary pancreatic duct confluence B-P type

    图  4  异常胆胰管合流P-B型

    Figure  4.  Abnormal biliopancreatic duct confluence P-B type

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  • 收稿日期:  2023-09-27
  • 录用日期:  2023-11-24
  • 出版日期:  2024-01-23
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