顶端钠依赖性胆汁酸转运蛋白（ASBT）在肝胆疾病中的作用

谢晓暄; 杜丽娜; 郭紫云; 杨燕

doi:10.12449/JCH240133

顶端钠依赖性胆汁酸转运蛋白（ASBT）在肝胆疾病中的作用

DOI: 10.12449/JCH240133

国家儿童医学中心，首都医科大学附属北京儿童医院中医科，北京 100045

基金项目:

国家自然科学基金 (82205184);

北京市属医院科研培育计划 (PZ2022027)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：谢晓暄负责文献检索及文章撰写；杜丽娜负责文章修改；郭紫云负责文献检索；杨燕负责指导及校正。

详细信息

通信作者:
杨燕， yy2303@sina.com （ORCID： 0000-0003-1070-9614）

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出版历程
- 收稿日期: 2023-03-29
- 录用日期: 2023-05-06
- 出版日期: 2024-01-23

Role of apical sodium-dependent bile acid transporter in hepatobiliary diseases

Department of Traditional Chinese Medicine，National Center for Children’s Health，Beijing Children’s Hospital，Capital Medical University，Beijing 100045，China

Research funding:

National Natural Science Foundation of China (82205184);

Bejing Municipal Administration of Hospital Incubating Program (PZ2022027)

More Information

Corresponding author: YANG yan， yy2303@sina.com （ORCID： 0000-0003-1070-9614）

摘要

摘要: 顶端钠依赖性胆汁酸转运蛋白（ASBT）是负责胆汁酸肠道重吸收的关键转运体，对维持胆汁酸和胆固醇稳态起重要作用，其表达受到转录因子、核受体和肠道微生物等多种因素的调控。ASBT的表达和功能异常会导致胆汁酸及胆固醇代谢紊乱，引起多种肝胆相关疾病。目前，ASBT作为一种治疗靶点已受到广泛关注。本文阐述了ASBT的生物学特征及表达调控机制，并对ASBT在肝胆疾病中的作用进行了综述，为相关疾病的治疗提供新方向。
- 顶端钠依赖性胆汁酸转运蛋白 /
- 胆汁酸类 /
- 胆汁淤积
Abstract: Apical sodium-dependent bile acid transporter （ASBT） is a key transporter responsible for intestinal reabsorption of bile acid and plays an important role in maintaining bile acid and cholesterol homeostasis， and its expression is regulated by various factors including transcription factors， nuclear receptors， and intestinal microflora. The abnormal expression and function of ASBT can lead to disorders in the metabolism of bile acid and cholesterol， causing a variety of hepatobiliary diseases. At present， ASBT has attracted wide attention as a therapeutic target. This article elaborates on the biological characteristics and expression regulation mechanism of ASBT and reviews the role of ASBT in hepatobiliary diseases， in order to provide a new direction for the treatment of related diseases.
- Apical Sodium Dependent Bile Acid Transporter /
- Bile Acid /
- Cholestasis

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根据《世界医学协会赫尔辛基宣言》《涉及人的健康相关研究国际伦理准则》和我国《涉及人的生物医学研究伦理审查办法》《人体器官移植条例》《人类辅助生殖技术和人类精子库伦理原则》《药物临床试验伦理审查工作指导原则》等的相关规定以及国际通行的动物福利和伦理准则，本刊要求：

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