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半乳糖凝集素-9（Gal-9）介导的免疫调节作用在肝脏疾病中的研究进展
DOI: 10.12449/JCH240132
利益冲突声明：本文不存在任何利益冲突。
作者贡献声明：凌珺负责查找文献、撰写论文；朱冰负责拟定写作思路；陈威巍、王卓然负责修改论文；余丽梅、游绍莉负责拟定写作思路，指导撰写文章，修改论文并最后定稿。余丽梅与游绍莉对本文贡献等同，同为第一作者。
Research advances in the immunomodulatory mechanism of galectin-9 and its role in liver diseases
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摘要: 半乳糖凝集素-9（Gal-9）是能够特异性识别、结合半乳糖苷的半乳糖凝集素家族成员之一。近年研究发现，Gal-9在肝脏中高水平表达，有助于维持肝内免疫稳态并在多种肝脏疾病中发挥生物学功能。本文综述了Gal-9的免疫调节功能及其在不同肝脏疾病中的作用。Gal-9在不同肝脏疾病中通过多种途径发挥重要的生物学功能，基于对Gal-9具体免疫调节机制和功能的研究，有助于发现Gal-9在肝脏疾病中的治疗作用。Abstract: Galectin-9 （Gal-9） is a member of the galectin family that can specifically recognize and bind to galactosides. Recent studies have shown that Gal-9 is highly expressed in the liver and can help to maintain intrahepatic immune homeostasis and perform biological functions in various liver diseases. This article reviews the immunomodulatory functions of Gal-9 and its role in different liver diseases. Studies have shown that Gal-9 has important biological functions in different liver diseases through multiple pathways. Research on the specific immunomodulatory mechanisms and functions of Gal-9 may help to discover the therapeutic role of Gal-9 in liver diseases.
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Key words:
- Galectin-9 /
- Immunomodulation /
- Liver Diseases
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