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半乳糖凝集素-9(Gal-9)介导的免疫调节作用在肝脏疾病中的研究进展

凌珺 朱冰 陈威巍 王卓然 余丽梅 游绍莉

引用本文:
Citation:

半乳糖凝集素-9(Gal-9)介导的免疫调节作用在肝脏疾病中的研究进展

DOI: 10.12449/JCH240132
基金项目: 

国家科技重大专项资助 (2017ZX10203201);

国家重点研发计划资助 (2021YFC2301801)

利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:凌珺负责查找文献、撰写论文;朱冰负责拟定写作思路;陈威巍、王卓然负责修改论文;余丽梅、游绍莉负责拟定写作思路,指导撰写文章,修改论文并最后定稿。余丽梅与游绍莉对本文贡献等同,同为第一作者。
详细信息
    通信作者:

    余丽梅, ylm720@sina.com (ORCID: 0000-0002-3377-1202)

    游绍莉, youshaoli1972@163.com (ORCID: 0000-0001-8689-8509)

Research advances in the immunomodulatory mechanism of galectin-9 and its role in liver diseases

Research funding: 

National Science and Technology Major Project (2017ZX10203201);

Funded Projects of National Key R & D Program (2021YFC2301801)

More Information
  • 摘要: 半乳糖凝集素-9(Gal-9)是能够特异性识别、结合半乳糖苷的半乳糖凝集素家族成员之一。近年研究发现,Gal-9在肝脏中高水平表达,有助于维持肝内免疫稳态并在多种肝脏疾病中发挥生物学功能。本文综述了Gal-9的免疫调节功能及其在不同肝脏疾病中的作用。Gal-9在不同肝脏疾病中通过多种途径发挥重要的生物学功能,基于对Gal-9具体免疫调节机制和功能的研究,有助于发现Gal-9在肝脏疾病中的治疗作用。

     

  • 图  1  Gal-9免疫调节通路示意图

    Figure  1.  Schematic diagram of Gal-9 immunomodulatory pathway

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  • 收稿日期:  2023-04-18
  • 录用日期:  2023-05-23
  • 出版日期:  2024-01-23
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