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摘要: 慢加急性肝衰竭病情复杂、进展快、病死率高,其发病机制、病因等仍有待进一步研究阐明。而通过慢加急性肝衰竭动物模型的建立,不仅能为慢加急性肝衰竭的发病机制研究提供良好的基础,而且能为临床治疗提供实验依据。通过对相关文献的梳理,总结了目前常用的建立慢加急性肝衰竭动物模型的方法,包括CCl4联合脂多糖(LPS)/D-氨基半乳糖胺法、硫代乙酰胺联合LPS法、血清白蛋白法、胆管结扎术法等。通过分析各种动物模型的特点,为进一步探索更理想的动物模型提供文献基础和实验依据。Abstract: Acute-on-chronic liver failure has complex conditions, rapid progression, and a high mortality rate, and further studies are still needed to clarify its pathogenesis and etiology. The establishment of animal models for acute-on-chronic liver failure can not only provide a good basis for exploring the pathogenesis of acute-on-chronic liver failure, but also provide an experimental basis for clinical treatment. Through a literature review, this article summarizes the methods commonly used to establish the animal models of acute-on-chronic liver failure, including carbon tetrachloride combined with LPS/GaIN, thioacetamide combined with LPS, serum albumin, and bile duct ligation. This article analyzes the characteristics of various animal models, so as to provide documentary and experimental bases for further exploration of more ideal animal models.
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Key words:
- Liver Diseases /
- Acute-On-Chronic Liver Failure /
- Models, Animal
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