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肝硬化并发门静脉血栓的危险因素与防护策略

冯文娟 周宁 汪雨露 白兆琴

引用本文:
Citation:

肝硬化并发门静脉血栓的危险因素与防护策略

DOI: 10.12449/JCH240128
基金项目: 

甘肃省科技厅重点研发项目 (21YF5FA169)

兰州市人才创新创业项目 (2021-RC-107)

利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:冯文娟负责文献检索、文章构思并撰写论文;周宁负责指导论文撰写与修改;汪雨露、白兆琴参与文献检索和文献分析。
详细信息
    通信作者:

    周宁, zhouning198278@163.com (ORCID: 0000-0001-8988-2860)

Portal vein thrombosis in liver cirrhosis: Risk factors and protection strategies

Research funding: 

Key Research and Development Project of Science and Technology Department of Gansu Province (21YF5FA169);

Lanzhou Talent Innovation and Entrepreneurship Project (2021-RC-107)

More Information
  • 摘要: 门静脉血栓(PVT)形成是肝硬化自然病程中的常见并发症之一,对肝硬化进展有重要影响。本文着重总结了PVT发生的危险因素、预后等方面的研究进展。PVT形成的危险因素较多,Virchow三要素即门静脉血流阻滞、血液高凝状态、手术或创伤引起的血管内皮损伤以及全身炎症等被认为是PVT发生发展的主要原因。目前具有临床应用前景的PVT发生风险预测模型尚需更多前瞻性研究验证。肝硬化PVT患者的预后较差,完全闭塞性PVT与肝移植术后病死率升高相关。肝硬化患者预防性抗凝治疗已被证实安全有效,将有助于PVT的防治管理。

     

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