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巨噬细胞在原发性胆汁性胆管炎发病中的作用机制及影响

马狄 邰文琳

引用本文:
Citation:

巨噬细胞在原发性胆汁性胆管炎发病中的作用机制及影响

DOI: 10.12449/JCH240126
基金项目: 

国家自然科学基金 (82060385)

昆明医科大学2023年研究生创新基金 (2023S321)

利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:马狄负责收集资料及文章撰写;邰文琳负责文章修改及定稿。
详细信息
    通信作者:

    邰文琳, taiwenlin2685@163.com (ORCID: 0000-0002-8278-929X)

The role and impact of macrophages in the pathogenesis of primary biliary cholangitis

Research funding: 

National Natural Science Foundation of China (82060385);

The Postgraduate Innovation Fund Project of Kunming Medical University 2023 (2023S321)

More Information
  • 摘要: 原发性胆汁性胆管炎(PBC)是一种以肝内胆汁淤积为特征表现的慢性自身免疫性疾病,免疫因素导致进行性小胆管破坏,胆汁淤积,最终发展为肝纤维化、肝硬化甚至肝衰竭。巨噬细胞作为一群具有功能异质性的群体,在PBC整个疾病进程中发挥着不同的作用。本文归纳了巨噬细胞参与PBC发病机制的可能方式,讨论了其对PBC的影响及相关潜在治疗靶点。本文指出巨噬细胞主要参与了PBC损伤中的先天性免疫,且与肠道微生物失调相联系,在疾病后期与胆汁淤积、肝纤维化、肝硬化有关。

     

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出版历程
  • 收稿日期:  2023-03-25
  • 录用日期:  2023-04-15
  • 出版日期:  2024-01-23
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