慢性肝病肝纤维化无创诊断的研究进展

程捷瑶; 马红

慢性肝病肝纤维化无创诊断的研究进展

程捷瑶,
马红

首都医科大学附属北京友谊医院肝病中心

详细信息

中图分类号: R575.2
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- 被引次数: 0
出版历程
- 出版日期: 2014-02-20

摘要

摘要: 肝活组织检查因其有创性和样本误差,使其临床应用受限,近年来无创诊断与评价肝纤维化成为研究热点之一。介绍了目前主要的血清学模型和FibroScan对肝纤维化诊断的价值,并简述了无创方法的联合应用。现阶段无创诊断方法尚不能完全取代肝活组织检查,不同肝纤维化无创诊断方法对不同病因肝纤维化的诊断价值是否存在差异尚须进一步研究。
- 肝硬化 /
- 无创诊断 /
- 综述
Abstract: The clinical application of liver biopsy is limited due to its invasiveness and sample errors. In recent years, noninvasive diagnosis and assessment of liver fibrosis have become one of the research hotspots. The values of main serological models and FibroScan for the diagnosis of liver fibrosis are presented, and the joint use of noninvasive diagnostic methods is also covered. Currently, liver biopsy cannot be completely replaced by noninvasive diagnostic methods, and further study is needed to investigate whether there are differences between the diagnostic values of noninvasive diagnostic methods for liver cirrhosis of different causes.

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参考文献(30)

[1]SEBASTIANI G.Non-invasive assessment of liver fibrosis in chronic liver diseases:implementation in clinical practice and decisional algorithms[J].World J Gastroenterol, 2009, 15 (18) :2190-2203.

[2]GUO R, YAN M.Research progress in mechanisms of cellular and molecular in liver fibrosis[J].Chin J Liver Dis:Electron Vers, 2012, 4 (4) :57-62. (in Chinese) 郭蓉, 阎明.肝纤维化的细胞和分子机制研究进展[J].中国肝脏病杂志:电子版, 2012, 4 (4) :57-62.

[3] GUCHOT J, LAUDAT A, LORIA A, et al.Diagnostic accuracy of hyaluronan and type III procollagen amino-terminal peptide serum assays as markers of liver fibrosis in chronic viral hepatitis C evaluated by ROC curve analysis[J].Clin Chem, 1996, 42 (4) :558-563.

[4]MCHUTCHISON JG, BLATT LM, de MEDINA M, et al.Measurement of serum hyaluronicacid in patients with chronic hepatitis C and its relationship to liver histology.Consensus Interferon Study Group[J].J Gastroenterol Hepatol, 2000, 15 (8) :945-951.

[5]NAVEAU S, RAYNARD B, RATZIU V, et al.Biomarkers for the prediction of liver fibrosis in patients with chronic alcoholic liver disease[J].Clin Gastroenterol Hepatol, 2005, 3 (2) :167-174.

[6] SANTOS VN, LEITE-MR, KONDO M, et al.Serum laminin, type IV collagen and hyaluronan as fibrosis markers in non-alcoholic fatty liver disease[J].Braz J Med Biol Res, 2005, 38 (5) :747-753.

[7]WANG Y, LU LG.The current research on evaluating the progress of liver fibrosis by serum markers[J].J Clin Hepatol, 2011, 27 (8) :877-880. (in Chinese) 王燕, 陆伦根.评估肝纤维化进展相关的血清标志物研究现状[J].临床肝胆病杂志, 2011, 27 (8) :877-880.

[8]BOEKER KH, HABERKORN CI, MICHELS D, et al.Diagnostic potential of circulating TIMP-1 and MMP-2 as markers of liver fibrosis in patients with chronic hepatitis C[J].Clin Chim Acta, 2002, 316 (1-2) :71-81.

[9]WAI CT, GREENSON JK, FONTANA RJ, et al.A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C[J].Hepatology, 2003, 38 (2) :518-526.

[10]SHAHEEN AA, MYERS RP.Diagnostic accuracy of the aspartate aminotransferase-to-platelet ratio index for the prediction of hepatitis C-related fibrosis:a systematic review[J].Hepatology, 2007, 46 (3) :912-921.

[11]FORNS X, AMPURDANS S, LLOVET JM, et al.Identification of chronic hepatitis C patients without hepatic fibrosis by a simple predictive model[J].Hepatology, 2002, 36 (4 Pt 1) :986-992.

[12]IMBERT-BISMUT F, RATZIU V, PIERONI L, et al.Biochemical markers of liver fibrosis in patients with hepatitis C virus infection:a prospective study[J].Lancet, 2001, 357 (9262) :1069-1075.

[13]SEBASTIANI G, VARIO A, GUIDO M, et al.Sequential algorithms combining non-invasive markers and biopsy for the assessment of liver fibrosis in chronic hepatitis B[J].World J Gastroenterol, 2007, 13 (4) :525-531.

[14]MYERS RP, TAINTURIER MH, RATZIU V, et al.Prediction of liver histological lesions with biochemical markers in patients with chronic hepatitis B[J].J Hepatol, 2003, 39 (2) :222-230.

[15] NAVEAU S, RAYNARD B, RATZIU V, et al.Biomarkers for the prediction of liver fibrosis in patients with chronic alcoholic liver disease[J].Clin Gastroenterol Hepatol, 2005, 3 (2) :167-174.

[16] RATZIU V, MASSARD J, CHARLOTTE F, et al.Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease[J].BMC Gastroenterol, 2006, 6:6.

[17]MYERS RP, BENHAMOU Y, IMBERT-BISMUT F, et al.Serum biochemical markers accurately predict liver fibrosis in HIV and hepatitis C virus co-infected patients[J].AIDS, 2003, 17 (5) :721-725.

[18]ROSENBERG WM, VOELKER M, THIEL R, et al.Serum markers detect the presence of liver fibrosis:a cohort study[J].Gastroenterology, 2004, 127 (6) :1704-1713.

[19]CALES P, OBERTI F, MICHALAK S, et al.A novel panel of blood markers to assess the degree of liver fibrosis[J].Hepatology, 2005, 42 (6) :1373-1381.

[20]WU SD, WANG JY, LI L.Staging of liver fibrosis in chronic hepatitis B patients with a composite predictive model:a comparative study[J].World J Gastroenterol, 2010, 16 (4) :501-507.

[21] ZHOU K, GAO CF, ZHAO YP, et al.Simpler score of routine laboratory tests predicts liver fibrosis in patients with chronic hepatitis B[J].J Gastroenterol Hepatol, 2010, 25 (9) :1569-1577.

[22]WANG YJ, TANG SH.Assessment of hepatic fibrosis stage by transient elastography:an meta-analysis[J].Chin J Med Imaging Technol, 2012, 28 (3) :529-533. (in Chinese) 王一娇, 唐少珊.瞬时弹性成像评价肝纤维化分级的Meta分析[J].中国医学影像技术, 2012, 28 (3) :529-533.

[23]CASTRA L, VERGNIOL J, FOUCHER J, et al.Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C[J].Gastroenterology, 2005, 128 (2) :343-350.

[24]OLIVERI F, COCO B, CICCOROSSI P, et al.Liver stiffness in the hepatitis B virus carrier:a non-invasive marker of liver disease influenced by the pattern of transaminases[J].World J Gastroenterol, 2008, 14 (40) :6154-6162.

[25]COCO B, OLIVERI F, MAINA AM, et al.Transient elastography:a new surrogate marker of liver fibrosis influenced by major changes of transaminases[J].J Viral Hepat, 2007, 14 (5) :360-369.

[26]GANNE-CARRIE N, ZIOL M, de LEDINGHEN V, et al.Accuracy of liver stiffness measurement for the diagnosis of cirrhosis in patients with chronic liver diseases[J].Hepatology, 2006, 44 (6) :1511-1517.

[27]FOUCHER J, CHANTELOUP E, VERGNIOL J, et al.Diagnosis of cirrhosis by transient elastography (FibroScan) :a prospective study[J].Gut, 2006, 55 (3) :403-408.

[28]ZIOL M, HANDRA-LUCA A, KETTANEH A, et al.Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with chronic hepatitis C[J].Hepatology, 2005, 41 (1) :48-54.

[29]SEBASTIANI G, HALFON P, CASTERA L, et al.SAFE biopsy:a validated method for large-scale staging of liver fibrosis in chronic hepatitis C[J].Hepatology, 2009, 49 (6) :1821-1827.

[30]CASTRA L, SEBASTIANI G, LE BAIL B, et al.Prospective comparison of two algorithms combining non-invasive methods for staging liver fibrosis in chronic hepatitis C[J].J Hepatol, 2010, 52 (2) :191-198.

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