Role of Th17 cells in common liver diseases
-
摘要:
近年研究发现,Th17细胞是一类新的CD4+Th细胞亚群,在多种肝脏疾病的发生发展中起到重要作用,成为免疫学领域关注和研究的焦点。本文详细阐述了Th17细胞与各类肝脏疾病关系的研究概况,以期为肝脏相关疾病的研究和治疗提供新思路。
Abstract:In recent years, it has been found that T helper type 17 (Th17) cells are a new subset of CD4+ Th cells.Th17 cells play an important role in the onset and development of many liver diseases and have become the research focus in immunology.This paper summarizes the studies on the relationship between Th17 cells and various liver diseases in order to provide a new idea for the study and treatment of liver diseases.
-
Key words:
- T-lymphocyte /
- cytokines /
- liver diseases
-
[1]Linda H, Felix H, Frank T.Role of IL-17 and Th17 cells in liverdiseases[J].Clin Dev Immunol, 2011, 2011:345803. [2]Fu LZ, Li QH.The progression of research on the Th17 lineage[J].JClin Pulm Med, 2011, 16 (4) :582-584. (in Chinese) 付立主, 李其皓.Th17细胞的研究进展[J].临床肺科杂志, 2011, 16 (4) :582-584. [3]Nurieva R, Yang XO, Martine G, et al.Essential autocrine regula-tion by IL-21 in the generation of inflammation T cells[J].Na-ture, 2007, 448 (7152) :480-483. [4]Wang LY, Meng QH, Zou ZQ, et al.Increased frequency of circu-lating Th17 cells in acute-on-chronic hepatitis B liver failure[J].Dig Dis Sci, 2012, 57 (3) :667-674. [5]Ji L.The progression of research on the Th17 lineage[J].Int J LabMed, 2011, 32 (16) :1845-1847. (in Chinese) 季荔.Th17细胞的研究进展[J].国际检验医学杂志, 2011, 32 (16) :1845-1847. [6]Zhang F, Yao SM, Yuan J, et al.Elevated IL-6 receptor expres-sion on CD4+T cells contributes to the increased Th17 responses inpatients with chronic hepatitis B[J].Virol J, 2011, 8:270. [7]Lemmers A, Moreno C, Gustot T, et al.The interleukin-17 path-way is involved in human alcoholic liver disease[J].Hepatology, 2009, 49 (2) :646-657. [8]Ouyang W, Kolls JK, Zheng Y.The biological functions of T helper17 cell effector cytokines in inflammation[J].Immunity, 2008, 28 (4) :454-467. [9]Zhang Y, Huang CX, Wang JP, et al.The role of Th17 cells in liv-er diseases[J].Chin J Hepatol, 2012, 20 (4) :316-318. (inChinese) 张野, 黄长形, 王九平, 等.Th17细胞在肝脏疾病中的作用[J].中华肝脏病杂志, 2012, 20 (4) :316-318. [10]Zhang JY, Zhang Z, Wang FS, et al.Interleukin-17-producingCD4 (+) T cells increase with severity of liver damage in patientswith chronic hepatitis B[J].Hepatology, 2010, 51 (1) :81-91. [11]Chang Q, Wang YK, Zhao Q, et al.Th17 cells are increased with se-verity of liver inflammation in patients with chronic hepatitis C[J].Gastroenterol Hepatol, 2012, 27 (2) :273-278. [12]Jimenez-Sousa MA, Almansa R, de La Fuente C, et al.IncreasedTh1, Th17 and pro-fibrotic responses in hepatitis C-infected pa-tients are down-regulated after 12 weeks of treatment with pegylat-ed interferon plus ribavirin[J].Eur Cytokine Netw, 2010, 21 (2) :84-91. [13]Sun HQ, Zhang JY, Zhang H, et al.Increased Th17 cells contribute todisease progression in patients with HBV-associated liver cirrhosis[J].Viral Hepat, 2012, 19 (6) :396-403. [14]Li J, Qiu SJ, She WM, et al.Significance of the balance betweenregulatory T (Treg) and T helper 17 (Th17) cells during hepatitisB virus related liver fibrosis[J].PLoS One, 2012, 7 (6) :e39307. [15]Gao B, Waisman A.Th17 cells regulate liver fibrosis by targetingmultiple cell types:many birds with one stone[J].Gastroenterolo-gy, 2012, 143 (3) :536-539. [16]Hou W, Kang HS, Kim BS.Th17 cells enhance viral persistenceand inhibit T cell cytotoxicity in a model of chronic virus infection[J].J Exp Med, 2009, 206 (2) :313-328. [17]Heller JJ, Qiu J, Zhou L.Nuclear receptors take center stage in Th17cell-mediated autoimmunity[J].J Clin Invest, 2011, 121 (2) :519-521. [18]Rong G, Zhou Y, Xiong Y, et al.Imbalance between T helper type 17and T regulatory cells in patients with primary biliary cirrhosis:the ser-um cytokine profile and peripheral cell popula-tion[J].Clin Exp Im-munol, 2009, 156 (2) :217-225. [19]Harada K, Shimoda S, Sato Y, et al.Periductal interleukin-17 pro-duction in association with biliary innate immunity contributes to thepathogenesis of cholangiopathy in primary biliary cirrhosis[J].ClinExp Immunol, 2009, 157 (2) :261-270. [20]Li J, Lai X, Liao W, et al.The dynamic changes of Th17/Treg cy-tokines in rat liver transplant rejection and tolerance[J].Int Immu-nopharmacol, 2011, 11 (8) :962-967. [21]Fábrega E, López-Hoyos M, San Segundo D, et al.Changes in theserum levels of interleukin-17/interleukin-23 during acute rejectionin liver transplantation[J].Liver Transp, 2009, 15 (6) :629-633. [22]Burrell BE, Bishop Dk.Th17 cells and transplant acceptance[J].Transpl-antation, 2010, 90 (9) :945-948. [23]Yang B, Zhao CY.Advanced research on Th17 cell and its relevantrole in the progress liver diseases[J].J Clin Hepatol, 2011, 27 (2) :206-209. (in Chinese) 杨波, 赵彩彦.Th17细胞及其在相关肝病中的作用[J].临床肝胆病杂志, 2011, 27 (2) :206-209. [24]Liu LG, Lun WH.Research progress in the immunological effect ofTh17 cells in co-infection with HIV and Mycobacterium tuberculo-sis[J].Chin J Exp&Clin Infec Dis (Electron Version) [J].2012, 6 (1) :54-56. (in Chinese) 刘丽改, 伦文辉.Th17细胞在HIV合并结核分枝杆菌感染免疫中的作用研究进展[J].中华实验和临床感染病杂志 (电子版) , 2012, 6 (1) :54-56.
计量
- 文章访问数: 2987
- HTML全文浏览量: 12
- PDF下载量: 700
- 被引次数: 0