胰岛素样生长因子-I受体异常激活与肝癌靶向治疗

严晓娣; 董志珍; 姚登福

胰岛素样生长因子-I受体异常激活与肝癌靶向治疗

南通大学附属医院临床医学研究中心

基金项目:

南通市社会事业科技创新计划(HS2012039)；江苏省临床医学科技专项(BL2012053)；

详细信息

中图分类号: R735.7
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出版历程
- 出版日期: 2013-06-20

Abnormal activation of insulin-like growth factor-I receptor in hepatocellular carcinoma and potential of IGF-IR targeted therapy

Research Center of Clinical Medicine, Affiliated Hospital of Nantong University

Research funding:

摘要

摘要:
肝细胞恶性转化和癌变过程中,胰岛素样生长因子-I受体（IGF-IR）异常活化。IGF-IR过表达既可作为肝癌早期诊断的标志,又可作为肝癌靶向治疗的新靶点,且具有应用前景。本文对IGF-IR信号通路异常激活及分子靶向治疗肝癌等的研究进展作了综述。
- 肝肿瘤 /
- 受体,IGF1型 /
- 抗体,单克隆 /
- 微RNAs
Abstract:
Abnormal activation of the insulin-like growth factor-I receptor (IGF-IR) occurs during malignant transformation of hepatocytes and during hepatocarcinogenesis.IGF-IR overexpression has been proposed as a diagnostic biomarker for early-stage hepatocellular carcinoma (HCC) as well as a novel target for HCC therapy.This review summarizes the recent research of the IGF-IR signaling pathway's abnormal activation in HCC and the results of molecular targeting studies.
- liver neoplasms /
- receptor /
- IGF type I /
- antibodies

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参考文献(42)

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