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慢性HBV感染及其相关肝病患者外周血T细胞亚群的变化

王慰 郑欢伟 任桂芳 冯爱东 刘莲 李兵顺

引用本文:
Citation:

慢性HBV感染及其相关肝病患者外周血T细胞亚群的变化

基金项目: 

河北省卫生厅科研基金项目(20090607); 

详细信息
  • 中图分类号: R512.62

Differential profiles of T-cell subsets are present in peripheral blood of patients with various progressive forms of hepatitis B infection

Research funding: 

 

  • 摘要:

    目的观察不同临床类型HBV感染者外周血T淋巴细胞亚群的差异,探讨HBV对人体T细胞免疫的影响及其可能机制,不同类型慢性HBV感染者免疫失衡的规律。方法用流式细胞仪技术检测患者外周血T细胞亚群。慢性HBV感染者318例,其中HBV携带者8例,慢性乙型肝炎231例,肝炎后肝硬化61例,原发性肝癌18例,观察患者的T淋巴细胞亚群、HBV DNA等。同时收集22名健康志愿者的新鲜血检测T淋巴细胞亚群。结果不同临床类型HBV感染者外周血CD3+T、CD4+T、CD8+T细胞百分数低于正常对照组,差别均有统计学意义(P<0.05或P<0.01),cd4+ p="">0.05)。结论慢性HBV感染随着病情进展,由慢性肝炎→肝硬化→肝癌,直至细胞免疫功能逐渐衰退。慢性HBV感染的不同阶段的细胞免疫紊乱各具特点,就不同类型患者应采用不同的免疫调节治疗手段。

     

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  • 出版日期:  2013-04-20
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