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Differential distribution of age and HBV serological markers in liver cirrhosis and non-cirrhotic patients with primary liver cancer
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摘要:
目的探讨原发性肝癌(PHC)合并肝硬化与无肝硬化患者年龄及HBV血清学特点。方法回顾性分析经影像学检查及甲胎蛋白(AFP)测定诊断为PHC的患者547例,分为有肝硬化和无肝硬化两组,统计分析并比较其年龄分布及HBV血清学标记的特点。结果合并肝硬化与无肝硬化患者分别为265例及282例,两组伴HBV感染者分别为221例、256例。合并肝硬化的肝癌患者男女比例为7.83∶1;60岁以下的男性肝癌患者年龄分布无明显差异,无肝硬化的男性肝癌患者60岁以上比例明显高于有肝硬化者(P<0.005)。合并肝硬化的男性肝癌患者HBV感染率40岁以下年龄组最高(96.67%),而HBeAg血清学转换率以40～60岁年龄段最高(89.47%);无肝硬化者HBV感染率40～60岁年龄段最高(90.43%),但HBeAg血清学转换率最低(80%)。结论合并肝硬化的PHC患者中,男性占大多数,而且早年HBV感染率高;无肝硬化的PHC患者中,老年人占多数;HBeAg血清学转换率高的人群肝癌发病率相对较高。
Abstract:Objective To compare the age distributions and presence of hepatitis B virus (HBV) serological markers between primary hepatic cancer (PHC) patients with and without liver cirrhosis.Methods A total of 547 PHC cases were analyzed retrospectively.After dividing into two groups according to liver cirrhosis status, the between-group differences in age and HBV serological markers, such as hepatitis B e antigen (HBeAg) status, were statistically compared using the Chi-squared test.Results The number of cirrhotic and non-cirrhotic PHC patients was 265 and 282, respectively.HBV infection was present in 221 cirrhotic PHC patients and 256 non-cirrhotic PHC patients (83.4% vs.90.8%) .There was a substantial bias in the proportion of males to females in the cirrhotic PHC patients (7.83∶ 1) .The number of PHC patients<60 years="" old="" was="" similar="" between="" the="" cirrhotic="" and="" non-cirrhotic="" but="" group="" had="" significantly="" more="" patients="">60 years old (P<0.005) .In cirrhotic PHC patients, the HBV infection rate was highest in the <40 years old age group (96.7%) and the HBeAg serological conversion rate was highest in the 40-60 years old age group (89.5%) .In non-cirrhotic PHC patients, the 40-60 years old age group showed the highest HBV infection rate (90.3%) but the lowest HBeAg serological conversion rate (80.0%) .Conclusion PHC with liver cirrhosis mainly occurred in males, with the HBV infection rate being higher in individuals <60 years="" old.non-cirrhotic="" phc="" patients="" were="" more="" often="">60 years old.Many of the HBV-infected PHC patients with cirrhosis had high HBeAg serological conversion rate.
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Key words:
- liver neoplasms /
- liver cirrhosis /
- hepatitis B /
- chronic
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