Recent perspectives on the role of microRNAs of the miR-15 family in liver disease
-
摘要:
微小RNA(miRNA)是一类最新发现的短小内源性非编码RNA,其中miR-15家族生理状态下参与细胞凋亡、分化与周期调控、应激等重要细胞功能活动的调节,而在病理状态下与多种人类疾病如肿瘤、心血管疾病、神经退行性疾病等相关,具有潜在的治疗前景。本文就miR-15家族在肝癌、急性肝衰竭、肝纤维化和慢性肝病中的重要功能及治疗应用前景作一综述。
Abstract:Since their recent discovery, microRNAs (miRNAs) , a class of short endogenous non-coding RNAs, have gained substantial research attention for their critical roles in a broad range of physiologic and pathogenic processes.Under normal physiological conditions, the miR-15 family members regulate several important cellular functions, including apoptosis, cell differentiation, cell cycle, and stress responses.However, under pathological conditions, the miR-15 family members contribute to carcinogenesis, cardiovascular dysfunctions, and neurodegeneration;these activities may represent potentially useful targets of molecular therapeutic strategies.In this review, we summarize and discuss the important functions and promising therapeutic applications of the miR-15 family in liver cancer, acute liver failure, liver fibrosis, and liver damage.
-
Key words:
- microRNAs /
- hepatitis /
- chronic /
- liver cirrhosis /
- liver failure
-
[1]Bartel DP.MicroRNAs:genomics, biogenesis, mechanism, and function[J].Cell, 2004, 116 (2) :281-297. [2]Bartel DP.MicroRNAs:target recognition and regulatory func-tions[J].Cell, 2009, 136 (2) :215-233. [3]Axtell MJ, Westholm JO, Lai EC.Vive la difference:biogen-esis and evolution of microRNAs in plants and animals[J].Genome Biol, 2011, 12 (4) :221. [4]Lewis BP, Burge CB, Bartel DP.Conserved seed pairing, often lanked by adenosines, indicates that thousands of humangenes are microRNA targets[J].Cell, 2005, 120 (1) :15-20. [5]Bargaje R, Hariharan M, Scaria V, et al.Consensus miRNAexpression profiles derived from interplatform normalization ofmicroarray data[J].RNA, 2010, 16 (1) :16-25. [6]Yue J, Tigyi G.Conservation of miR-15a/16-1 and miR-15b/16-2 clusters[J].Mamm Genome, 2010, 21 (1-2) :88-94. [7]Benson AB 3rd, Abrams TA, Ben-Josef E, et al.NCCNclinical practice guidelines in oncogy:hepatobiliary cancers[J].J Nat Compr Canc Netw, 2009, 7 (4) :350-391. [8]Qu KZ, Zhang Ke, Li H, et al.Circulating MicroRNAs as bio-markers for hepatocellular carcinoma[J].J Clin Gastroen-terol, 2011, 45 (4) :355-360. [9]Chung GE, Yoon JH, Myung SJ, et al.High expression ofmicroRNA-15b predicts a low risk of tumor recurrence fol-lowing curative resection of hepatocellular carcinoma[J].Oncol Rep, 2010, 23 (1) :113-119. [10]Liu AM, Yao TJ, Wang W.Circulating miR-15b and miR-130b in serum as potential markers for detecting hepatocellu-lar carcinoma:a retrospective cohort study[J].BMJ open, 2012, 2 (2) :e000825. [11]Huang YH, Lin KH, Chen HC, et al.Identification of postop-erative prognostic MicroRNA predictors in hepatocellular car-cinoma[J].PLoS One, 2012, 7 (5) :e37188. [12]Skawran B, Steinemann D, Becker T, et al.Loss of 13q isassociated with genes involved in cell cycle and proliferationin dedifferentiated hepatocellular carcinoma[J].Mod Pathol, 2008, 21 (12) :1479-1489. [13]Tsang WP, Kwok TT.Epigallocatechin gallate up-regulationof miR-16 and induction of apoptosis in human cancer cells[J].J Nutr Biochem, 2010, 21 (2) :140-146. [14]Tsang TY, Tang WY, Chan JY, et al.P-glycoprotein en-hances radiation-induced apoptotic cell death through theregulation of miR-16 and Bcl-2 expressions in hepatocellu-lar carcinoma cells[J].Apoptosis, 2011, 16 (5) :524-535. [15]Bottoni A, Piccin D, Tagliati F, et al.miR-15a and miR-16-1 down-regulation in pituitary adenomas[J].J Cell Phys-iol, 2005, 204 (1) :280-285. [16]Bandi N, Zbinden S, Gugger M, et al.miR-15a and miR-16 are implicated in cell cycle regulation in a Rb dependentmannerand are frequently deleted or down regulated in non-small cell lung cancer[J].Cancer Res, 2009, 69 (13) :5553-5559. [17]Bonci D, Coppola V, Musumeci M, et al.The miR-15amiR-16-1 cluster controls prostate cancer by targetingmultiple oncogenic activities[J].Nat Med, 2008, 14 (11) :1271-1277. [18]Linsley PS, Schelter J, Burchard J, et al.Transcripts targetedby the microRNA-16 family cooperatively regulate cell cycleprogression[J].Mol Cell Biol, 2007, 27 (6) :2240-2252. [19]Wu G, Yu F, Xiao Z, et al.Hepatitis B virus X protein downreg-ulates expression of the miR-16 family in malignant hepato-cytes in vitro[J].Br J of Cancer, 2011, 105 (1) :146-153. [20] Xu T, Zhu Y, Xiong Y, et al.MicroRNA-195 suppresses tu-morigenicity and regulates G1/S transition of human hepatocel-lular carcinoma cells[J].Hepatology, 2009, 50 (1) :113-121. [21]Wu Z, Han M, Chen T, et al.Acute liver failure:mecha-nisms of immune-mediated liver injury[J].Liver Int, 2010, 30 (6) :782-794. [22] An F, Gong B, Wang H.miR-15b and miR-16 regulateTNF mediated hepatocyte apoptosis via BCL2 in acute liverfailure[J].Apoptosis, 2012, 17 (7) :702-716. [23]Li D, Friedman SL.Liver fibrogenesis and the role of hepaticstellate cell:new insights and prospects for therapy[J].JGastrcenterol Hepatol, 1999, 14 (7) :618-633. [24]Guo CJ, Pan Q, Li DG, et al.miR-15b and miR-16 areimplicated in activation of the rat hepatic stellate cell:An es-sential role for apoptosis[J].J Hepatol, 2009, 50 (4) :766-778. [25]Guo CJ, Pan Q, Jiang B, et al.Effects of upregulated ex-pression of microRNA-16 on biological properties of culture-activated hepatic stellate cells[J].Apoptosis, 2009, 14 (11) :1331-1340. [26]Peng X, Li Y, Walters KA, et al.Computational identification ofhepatitis C virus associated microRNA-mRNA regulatory mod-ules in human livers[J].BMC Genomics, 2009, 10:373. [27]Silvia C, Anna R, Jorge A, et al.Circulating microRNAs inpatients with chronic hepatit C and non-alcoholic fatty liverdisease[J].PLoS One, 2011, 6 (8) :e23937. [28]Zhang XY, Ni M, Chen SS, et al.Endogenous liver microRNAregulates HBV gene expression and replication[J].J Med MolBiol, 2008, 5 (3) :189-193. (in Chinese) 张小勇, 倪明, 陈姗姗, 等.肝脏内源性microRNA调控乙型肝炎病毒基因的表达与复制[J].医学分子生物学杂志, 2008, 5 (3) :189-193. [29]Otsuka M, Aizaki H, Kato N, et al.Differential cellular geneexpression induced by hepatitis B and C viruses[J].BBRC, 2003, 300 (2) :443-447. [30]Liu Y, Zhao JJ, Wang CM, et al.Altered expression profilesof microRNAs in a stable hepatitis B virus expressing cell line[J].CMJ, 2009, 122 (1) :10-14.
计量
- 文章访问数: 3566
- HTML全文浏览量: 12
- PDF下载量: 678
- 被引次数: 0