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唐山地区献血人群隐匿性乙型肝炎病毒感染分析

曹晓 曹庆宝 张国强 常在娟 李淑萍 徐微微

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唐山地区献血人群隐匿性乙型肝炎病毒感染分析

详细信息
  • 中图分类号: R512.62

Analysis of occult hepatitis B virus infection among blood donors in Tangshan, China

  • 摘要:

    目的了解唐山地区无偿献血人群隐匿性乙型肝炎感染情况。方法用ELISA法检测无偿献血者的乙型肝炎血清标志物,对于HBsAg阴性样本,进行HBV核酸检测(NAT),NAT阳性样本,用罗氏试剂确证HBV DNA载量。结果共检测116 741例血样,证实隐匿性乙型肝炎感染者35例,占总献血人数的0.29‰。其中97.1%隐匿性乙型肝炎感染者样本的HBV DNA滴度低于102IU/ml。在HBV DNA阳性人群中,抗-HBc阳性率较高,占81.5%,抗-HBs阳性或乙型肝炎病毒血清标志物全阴性也可检出HBV DNA分别占55.6%和22.9%。结论唐山地区献血人群中血清HBsAg阴性者存在一定比例的隐匿性HBV感染,其HBV病毒载量均较低,核酸检测能够提高HBV感染的检出率。

     

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  • 出版日期:  2013-02-20
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