胰腺癌的超声内镜诊治现状

张文颖; 金震东

胰腺癌的超声内镜诊治现状

第二军医大学附属长海医院消化内科

详细信息

中图分类号: R735.9
计量
- 文章访问数: 2658
- HTML全文浏览量: 25
- PDF下载量: 657
- 被引次数: 0
出版历程
- 出版日期: 2013-01-20

Diagnostic and therapeutic value of endoscopic ultrasonography for pancreatic cancer

摘要

摘要:
胰腺癌是我国常见肿瘤之一,5年生存率不到5%。由于胰腺癌早期缺乏典型临床表现,待明确诊断时90%患者已出现局部浸润及远处转移而无法行根治性切除。随着超声内镜(EUS)的出现,EUS在胰腺癌的诊断和治疗方面起着重要的作用。本文仅就EUS对胰腺癌的诊断和治疗进展作一综述。
- 胰腺肿瘤 /
- 腔内超声检查
Abstract:
Pancreatic cancer remains one of the most commonly diagnosed cancers in China, and the 5-year survival rate is less than 5%.The extremely low survival rate and poor prognosis stem from the lack of clinical manifestations in the disease's early stages.Endoscopic ultrasonography (EUS) is a highly sensitive technology that may facilitate earlier diagnosis of pancreatic cancer.In this review, we discuss the latest applications of EUS in pancreatic cancer and the implications for timely treatment initiation and improved therapeutic outcome.
- pancreatic neoplasms /
- endosonography

HTML全文

参考文献(30)

[1]Chang KJ, Nguyen P, Erickson RA, et al.The clinical utilityof endoscopic ultrasound-guided fine-needle aspiration inthe diagnosis and staging of pancreatic carcinoma[J].Gas-trointest Endosc, 1997, 45 (5) :387-393.

[2]Eloubeidi MA, Jhala D, Chhieng DC, et al.Yield of endo-scopic ultrasound-guided fine-needle aspiration biopsy inpatients with suspected pancreatic carcinoma[J].Cancer, 2003, 99 (5) :285-292.

[3]Agarwal B, Abu-Hamda E, Molke KL, et al.Endoscopic ul-trasound-guided fine needle aspiration and multidetectorspiral CT in the diagnosis of pancreatic cancer[J].Am JGastroenterol, 2004, 99 (5) :844-850.

[4]金震东, 蔡振寨, 李兆申, 等.内镜超声检查术对胰腺肿瘤早期诊断的价值[J].中华内科杂志, 2007, 46 (12) :984-987.

[5]Raut CP, Grau AM, Staerkel GA, et al.Diagnostic accuracyof endoscopic ultrasound-guided fine-needle aspiration inpatients with presumed pancreatic cancer[J].J GastrointestSurg, 2003, 7 (1) :118-126.

[6]邹晓平, 张斌, 李雯, 等.内镜超声引导下细针穿刺抽吸术对胰腺癌的诊断价值[J].中华消化内镜杂志, 2009, 26 (4) :184-187.

[7]Wang KX, Ben QW, Jin ZD, et al.Assessment of morbidityand mortality associated with EUS-guided FNA:a systemat-ic review[J].Gastrointest Endosc, 2011, 73 (2) :283-290.

[8]Shah SM, Ribeiro A, Levi J, et al.EUS-guided fine needleaspiration with and without trucut biopsy of pancreatic mas-ses[J].JOP, 2008, 9 (4) :422-430.

[9]Wang X, Gao J, Ren Y, et al.Detection of KRAS gene muta-tions in endoscopic ultrasound-guided fine-needle aspira-tion biopsy for improving pancreatic cancer diagnosis[J].Am J Gastroenterol, 2011, 106 (12) :2104-2111.

[10]Bhutani MS, Hoffman BJ, van Velse A, et al.Contrast-en-hanced endoscopic ultrasonography with galactose micropar-ticles:SHU508 A (Levovist) [J].Endoscopy, 1997, 29 (7) :635-639.

[11]Becker D, Strobel D, Bernatik T, et al.Echo-enhanced col-or-and power-Doppler EUS for the discrimination be-tween focal pancreatitis and pancreatic carcinoma[J].Gas-trointest Endosc, 2001, 53 (7) :784-789.

[12]Hocke M, Schulze E, Gottschalk P, et al.Contrast-en-hanced endoscopic ultrasound in discrimination between fo-cal pancreatitis and pancreatic cancer[J].World J Gastroen-terol, 2006, 12 (2) :246-250.

[13]Giovannini M, Hookey LC, Bories E, et al.Endoscopic ultra-sound elastography:the first step towards virtual biopsyPreliminary results in 49 patients[J].Endoscopy, 2006, 38 (4) :344-348.

[14]Giovannini M, Thomas B, Erwan B, et al.Endoscopic ultra-sound elastography for evaluation of lymph nodes and pan-creatic masses:a multicenter study[J].World J Gastroen-terol, 2009, 15 (13) :1587-1593.

[15]Iglesias-Garcia J, Larino-Noia J, Abdulkader I, et al., EUSelastography for the characterization of solid pancreatic masses[J].Gastrointest Endosc, 2009, 70 (6) :1101-1108.

[16]Saftoiu A, Vilmann P, Gorunescu F, et al.Neural network a-nalysis of dynamic sequences of EUS elastography used forthe differential diagnosis of chronic pancreatitis and pancreat-ic cancer[J].Gastrointest Endosc, 2008, 68 (6) :1086-1094.

[17]Zhang MM, Yang H, Jin ZD, et al.Differential diagnosis ofpancreatic cancer from normal tissue with digital imaging pro-cessing and pattern recognition based on a support vectormachine of EUS images[J].Gastrointestinal Endoscopy, 2010, 72 (5) :978-985.

[18]Hecht JR, Bedford R, Abbruzzese JL, et al.A phase I/II trialof intratumoral endoscopic ultrasound injection of ONYX-015 with intravenous gemcitabine in unresectable pancreaticcarcinoma[J].Clin Cancer Res, 2003, 9 (2) :555-561.

[19] 诸琦, 徐凯, 傅晖, 等.超声内镜引导基因重组人溶瘤腺病毒植入治疗晚期胰腺癌初步研究[J].中华消化内镜杂志, 2008, 25 (7) :341-346.

[20]肖斌, 金震东, 李兆申, 等.瘤内注射重组溶瘤病毒联合吉西他滨化疗治疗中晚期胰腺癌19例疗效观察[J].中华胰腺病杂志, 2011, 11 (3) :163-166.

[21]Du YQ, Li ZS, Jin ZD.Endoscope-assisted brachytherapyfor pancreatic cancer:From tumor killing to pain relief anddrainage[J].J Interv Gastroenterol, 2011, 1 (1) :23-27.

[22]Jin Z, Du Y, Li Z, et al.Endoscopic ultrasonography-guided interstitial implantation of iodine 125-seeds com-bined with chemotherapy in the treatment of unresectablepancreatic carcinoma:a prospective pilot study[J].Endos-copy, 2008, 40 (4) :314-320.

[23]Wiersema MJ, Wiersema LM.Endosonography-guided ce-liac plexus neurolysis[J].Gastrointest Endosc, 1996, 44 (6) :656-662.

[24]Wyse JM, Carone M, Paquin SC, et al.Randomized, doub-le-blind, controlled trial of early endoscopic ultrasound-guided celiac plexus neurolysis to prevent pain progression inpatients with newly diagnosed, painful, inoperable pancreaticcancer[J].J Clin Oncol, 2011, 29 (26) :3541-3546.

[25] 王洛伟, 金震东, 李兆申, 等.超声内镜引导下腹腔神经节阻滞术治疗癌性疼痛的临床研究[J].中华消化杂志, 2008, 28 (5) :297-300.

[26]Wang KX, Jin ZD, Du YQ, et al.EUS-guided celiac gangli-on irradiation with iodine-125 seeds for pain control in pan-creatic carcinoma:a prospective pilot study[J].GastrointestEndosc, 2012, 76 (5) :945-952.

[27]Schmidt T, Ziske C, Marten A, et al.Intratumoral immuniza-tion with tumor RNA-pulsed dendritic cells confers antitu-mor immunity in a C57BL/6 pancreatic murine tumor model[J].Cancer Res, 2003, 63 (24) :8962-8967.

[28]Matthes K, Mino-Kenudson M, Sahani DV, et al.EUS-guided injection of paclitaxel (OncoGel) provides therapeuticdrug concentrations in the porcine pancreas (with video) [J].Gastrointest Endosc, 2007, 65 (3) :448-453.

[29]Goldberg SN, Mallery S, Gazelle GS, et al.EUS-guided ra-diofrequency ablation in the pancreas:results in a porcinemodel[J].Gastrointest Endosc, 1999, 50 (3) :392-401.

[30]Chan HH, Nishioka NS, Mino M, et al.EUS-guided photo-dynamic therapy of the pancreas:a pilot study[J].Gastroint-est Endosc, 2004, 59 (1) :95-99.

施引文献

资源附件(0)

访问统计