替比夫定对慢性乙型肝炎患者血清中可溶性E选择素的影响

张雪华; 朱传武; 罗湘蓉; 柴晓哲

替比夫定对慢性乙型肝炎患者血清中可溶性E选择素的影响

苏州市第五人民医院传染科

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中图分类号: R512.62
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出版历程
- 出版日期: 2012-11-20

Therapeutic efficacy of telbivudine for treating chronic hepatitis B patients with elevated levels of serum soluble E-selectin

摘要

摘要:
目的观察替比夫定（LdT）治疗前后慢性乙型肝炎（CHB）患者HBsAg水平和血清中可溶性E选择素（sE-selectin）含量的变化。方法 107例CHB患者给予口服LdT 600 mg/d治疗,观察治疗前、治疗后第12、24和48周时患者HBsAg水平和血清中sE-selectin含量的变化,并进行相关性分析。结果 CHB患者血清sE-selectin含量明显高于健康对照组（P<0.01）。与治疗前相比,107例患者经LdT治疗后HBsAg水平和血清中sE-selectin含量均明显降低（P<0.01）。相关性分析表明,HBsAg水平和血清sE-selectin含量呈正相关（P<0.01）。结论 LdT可通过降低CHB患者血清中sE-selectin水平,提高免疫功能来抑制HBV复制。
- 替比夫定 /
- 肝炎,乙型,慢性 /
- E选择素
Abstract:
Objective To compare the levels of hepatitis B surface antigen (HBsAg) and serum soluble (s) E-selectin before and after telbivudine (LdT) treatment in patients with chronic hepatitis B (CHB) .Methods One-hundred-and-seven patients with CHB and 82 healthy controls were enrolled in the study.The levels of HBsAg and serum sE-selectin were measured by enzyme-linked immunosorbent assay (ELISA) before and after LdT treatment.The correlation between HBsAg and serum sE-selectin was analyzed by Pearson′s correlation analysis.Results The pre-treatment sE-selectin content of the CHB group was significantly higher than that of the healthy control group (P<0.01) .The levels of both HBsAg and sE-selectin were significantly reduced in the CHB group after treatment with LdT (P<0.01) .The correlation analysis showed that the HBsAg level was positively correlated with the content of sE-selectin (P<0.01) .Conclusion sLdT may inhibit HBV replication by decreasing the serum sE-selectin content, which may lead to an enhanced immune function.
- telbivudine /
- hepatitis B /
- chronic

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参考文献(11)

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