非酒精性脂肪性肝病与肝细胞癌关系的研究进展

代鸿华; 梅礼强

非酒精性脂肪性肝病与肝细胞癌关系的研究进展

重庆市綦江区人民医院外一科

详细信息

中图分类号: R575.5
计量
- 文章访问数: 2879
- HTML全文浏览量: 21
- PDF下载量: 723
- 被引次数: 0
出版历程
- 出版日期: 2012-10-20

Advances in nonalcoholic fatty liver disease and hepatocellular carcinoma research

摘要

摘要:
非酒精性脂肪性肝病(NAFLD)作为一种与机体代谢紊乱相关的疾病,其发病率呈逐年上升趋势,随之引起肝脏代谢功能失调及相关病程进展,最终发展为脂肪性肝炎、隐源性肝硬化,甚至有可能发展为肝细胞癌(HCC)。本文就NAFLD相关HCC的发病机制、危险因素、诊断等作一综述。
- 脂肪肝 /
- 癌,肝细胞 /
- 代谢疾病 /
- 危险因素
Abstract:
The incidence of nonalcoholic fatty liver disease (NAFLD) is continuing to rise.Substantial research efforts have been allocated to uncover the etiologies and pathogenic mechanisms of this disease.These studies have revealed that NAFLD initially manifests as metabolic disturbance of liver function and can progress to adiposis hepatica, idiopathic cirrhosis, and hepatocellular carcinoma (HCC) ;however, the molecular processes, risk factors, and diagnostic indicators of NAFLD have yet to be definitively established.In this review, we summarize and discuss the latest research findings on these topics in order to provide a comprehensive overview of the current knowledge of NAFLD progression to HCC and the aspects that remain to be elucidated.
- fatty liver /
- carcinoma /
- hepatocellular /
- metabolic diseases

HTML全文

参考文献(23)

[1]胡承雷, 刘玥.非酒精性脂肪肝的诊疗现状及展望[J].山西医药杂志, 2011, 40 (12) :1213-1215.

[2]Smith BW, Adams LA.Non-alcoholic fatty liver disease[J].Crit Rev Clin Lab Sci, 2011, 48 (3) :97-113.

[3]Tanaka M, Katayama F, Kato H, et al.Hepatitis B and C vi-rus infection and hepatocellular carcinoma in China:a reviewof epidemiology and control measures[J].J Epidemiol, 2011, 21 (6) :401-416.

[4]Ascha MS, Hanouneh IA, Lopez R, et al.The incidence andrisk factors of hepatocellular carcinoma in patients with nonal-coholic steatohepatitis[J].Hepatology, 2010, 51 (6) :1972-1978.

[5]刘晓燕, 李胜棉, 杨俭.1293例原发性肝癌患者非酒精性脂肪性肝病的伴发率及预后特征[J].临床肝胆病杂志, 2010, 26 (6) :641-643.

[6]Tilg H, Moschen AR.Evolution of inflammation in nonalco-holic fatty liver disease:the multiple parallel hits hypothesis[J].Hepatology, 2010, 52 (5) :1836-1846.

[7]常彬霞, 滕光菊.非酒精性脂肪性肝病的研究进展[J].传染病信息, 2011, 24 (5) :309-313.

[8]Wang Y, Ausman LM, Greenberg AS, et al.Nonalcoholicsteatohepatitis induced by a high-fat diet promotes dieth-ylnitrosamine-initiated early hepatocarcinogenesis in rats[J].Int J Cancer, 2009, 124 (3) :540-546.

[9]Rolo AP, Teodoro JS, Palmeira CM.Role of oxidative stressin the pathogenesis of nonalcoholic steatohepatitis[J].FreeRadic Biol Med, 2012, 52 (1) :59-69.

[10]Puri P, Mirshahi F, Cheung O, et al.Activation and dysregu-lation of the unfolded protein response in nonalcoholic fattyliver disease[J].Gastroenterology, 2008, 134 (2) :568-576.

[11]Caldwell S, Park SH.The epidemiology of hepatocellular canc-er:from the perspectives of public health problem totumor biol-ogy[J].J Gastroenterol, 2009, 44 (Suppl 19) :96-101.

[12]Yasui K, Hashimoto E, Komorizono Y, et al.Characteristicsof patients with nonalcoholic steatohepatitis who develophepatocellular carcinoma[J].Clin Gastroenterol Hepatol, 2011, 9 (5) :428-433.

[13]Tokushige K, Hashimoto E, Yatsuji S, et al.Prospective studyof hepatocellular carcinoma in nonalcoholic steatohepatitis incomparison with hepatocellular carcinoma caused by chronic hepatitis C[J].J Gastroenterol, 2010, 45 (9) :960-967.

[14]Duan XY, Qiao L, Fan JG.Clinical features of nonalcoholic fatty liver disease-associated hepatocellular carcinoma[J].Hepatobiliary Pancreat Dis Int, 2012, 11 (1) :18-27.

[15]El-Koofy NM, Anwar GM, El-Raziky MS, et al.The asso-ciation of metabolic syndrome, insulin resistance and non-alcoholic fatty liver disease in overweight/obese children[J].Saudi J Gastroenterol, 2012, 18 (1) :44-49.

[16]Aubert J, Begriche K, Knockaert L, et al.Increased expres-sion of cytochrome P4502E1in nonalcoholic fatty liver dis-ease:mechanisms and pathophysiological role[J].Clin Res Hepatol Gastroenterol, 2011, 35 (10) :630-637.

[17]Zelber-Sagi S, Ratziu V, Zvibel I, et al.The association be-tween adipocytokines and biomarkers for nonalcoholic fatty liv-er disease-induced liver injury:a study in the general popula-tion[J].Eur J Gastroenterol Hepatol, 2012, 24 (3) :262-269.

[18]杨汇娟, 海广范, 徐保福, 等.胰岛素抵抗伴非酒精性脂肪性肝病动物模型脂肪细胞瘦素的表达规律[J].广东医学, 2011, 32 (24) :3167-3169.

[19]Hashimoto E, Tokushige K.Hepatocellular carcinoma in non-alcoholic steatohepatitis:Growing evidence of an epidemic[J].Hepatol Res, 2012, 42 (1) :1-14.

[20]Fugita N, Takei Y.Iron overload in nonalcoholic steatohepati-tis[J].Adv Clin Chem, 2011, 55:105-132.

[21]Hamaguchi M, Kojima T, Ohbora A, et al.Aging is a risk factor of nonalcoholic fatty liver disease in premenopausal women[J].World J Gastroenterol, 2012, 18 (3) :237-243.

[22]Sugimoto K, Takei Y.Clinicopathological features of non-al-coholic fatty liver disease[J].Hepatol Res, 2011, 41 (10) :911-920.

[23]Iannaccone R, Piacentini F, Murakami T, et al.Hepatocellu-lar carcinoma in patients with nonalcoholic fatty liver disease:helical CT and MR imaging findings with clinical-pathologic comparison[J].Radiology, 2007, 243 (2) :422-430.

施引文献

资源附件(0)

访问统计