丙型肝炎肝硬化抗病毒治疗现状

张达利; 张敏; 苏海滨

丙型肝炎肝硬化抗病毒治疗现状

解放军第302医院移植内科

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中图分类号: R575.2
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出版历程
- 出版日期: 2012-09-20

Current perspectives on antiviral therapy for hepatitis C-related cirrhosis

摘要

摘要: 目前干扰素联合利巴韦林是慢性HCV感染的主要抗病毒治疗方案,但丙型肝炎肝硬化患者对于抗病毒治疗耐受性差。目前研究报道对于丙型肝炎肝硬化患者进行抗病毒治疗,如能获得持续病毒学应答(SVR),有利于缓解肝纤维化进展,并减少肝移植术后HCV再感染的发生。因此,应对丙型肝炎肝硬化患者进行仔细评估,对于进行抗病毒治疗的患者可给予适当干预以维持抗病毒治疗的进行,并在治疗过程中密切监测不良反应的发生。
- 肝炎,丙型,慢性 /
- 肝硬化 /
- 抗病毒药
Abstract: The most effective and widely used treatment for patients with chronic hepatitis C virus (HCV) infection is anti-viral therapy with a combination of interferon (IFN) and ribavirin.However, the tolerability for these drugs is low in patients with cirrhosis.Many studies have shown that HCV-related cirrhosis patients who achieve sustained viral response (SVR) after anti-viral therapy have significantly slower progression of liver fibrosis and a lower rate of HCV recurrence after liver transplantation.Therefore, patients with HCV-related cirrhosis should be monitored carefully to recognize and resolve adverse side effects of anti-viral treatments in a timely manner and to predict success of transplantation with non-recurrence.
- hepatitis C /
- chronic /
- liver cirrhosis

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参考文献(24)

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