Notch信号通路在肝癌中的研究进展

祝普利; 王德盛; 周亮; 苟泽鹏; 窦科峰

Notch信号通路在肝癌中的研究进展

第四军医大学附属西京医院肝胆外科

基金项目:

国家自然科学基金(30872480)；

详细信息

中图分类号: R735.7
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- 被引次数: 0
出版历程
- 出版日期: 2012-07-20

Research progress of Notch signaling pathway in hepatocellular carcinoma

Research funding:

摘要

摘要: Notch信号通路存在于多种动物体内,其家族成员的结构具有高度保守性,在细胞分化和发育中发挥着关键作用,保持着细胞增殖、分化和凋亡三者之间的动态平衡。异常活化的Notch信号可促使正常细胞向恶性转化,失控的Notch信号与肿瘤细胞的生长相关,Notch信号在大多数情况下作为癌基因促进肿瘤生长,但也发挥着诱导细胞分化、抑制肿瘤细胞增殖的作用。
- 受体,Notch /
- 肝肿瘤
Abstract: The Notch signaling pathways exist in many animals, the members of the family structure is highly conservative.It plays a key role in cell differentiation and development and maintains the balance between cell proliferation, differentiation and apoptosis.The abnormal activation of Notch signal can contribute to normal to malignant transformation, and uncontrolled Notch signaling which is related to the growth of tumor cells regulation.Notch signal often acts as cancer gene to promote tumor growth in most of cases, but can also lead to cell differentiation and inhibit tumor proliferation role.
- receptors /
- Notch

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参考文献(18)

[1]Jemal A, Bray F, Center MM, et al.Global cancer statistics[J].CA Cancer J Clin, 2011, 61:69-90.

[2]Fiuza UM, AriasAM.Cell and molecular biology of Notch[J].Endocrinol, 2007, 194 (3) :459-474.

[3]Fu YJ, Ye F, Lv WG, et al.Recent researches on the Notchsignaling pathway[J].Med Mol Biol, 2007, 4 (5) :447-450.

[4]Yunsun Nam Jon C Aster, Stephen C Blacklow.Notch signa-ling as a therapeutic target[J].curr Opin Chem Bio1, 2002, 6 (4) :501-509.

[5]Fabris L, Cadamuro M, Guido M, et al.Analysis of liver re-pair mechanisms in Alagille syndrome and biliary atresia re-veals a role for notch signaling[J].Am J Pathol, 2007, 171 (2) :641-653.

[6]Croquelois A, Blindenbacher A, Terracciano L, et al.Induc-ible inactivation of Notch1 causes nodular regenerative hyper-plasia[J].Hepatology, 2005, 41 (3) :487-496.

[7]Qi R, An H, Yu Y, et al.Notch signaling inhibits growth ofhepatocellular carcinoma though induction cell cycle arrestand apoptosis[J].Cancer Res, 2003, 63 (23) :8323-8329.

[8]Gao J, Song Y, Chen L, et al.Deregulated expression of Notchreceptors in human hepatocellular carcinoma[J].Digestive andLiver Disease, 2008, 40 (2) :114-121.

[9]Wang X N, Li P, Dou C Y, et al, Expression levels of Notchreceptors in liver cancer[J].Chin J Cancer Prev Treat, 2009, 18:1401-1404.

[10]Ren XX, Xu ZF, Huang JF, et al.Notch expression in hepa-tocellular carcinoma and it’s oncological significance[J].Ac-ta academice medicine Nantong, 2009, 29 (1) :25-27.

[11]Hu XB, Feng F, Wang YC, et al.Blockade of Notch signa-ling in tumor bearing mice may lead to tumor regression, pro-gression, or metastasis, depending on tumor cell types[J].Neoplasia, 2009, 11 (1) :32-38.

[12]Gramantieri L, Giovannini C, Lanzi A, et al.Aberrant Notch3and Notch4 expression in human hepatocellular carcinoma[J].Liver Int, 2007, 27 (7) :997-1007.

[13]Gao J, Chen C, Hong L, et al.Expression of Jagged1 andits association with hepatitis B virus X protein in hepatocellu-lar carcinoma[J].Biochem Biophys Res Commun, 2007, 356 (2) :341-347.

[14]Huang J, Zhang X, Zhu JD, et al.Up-regulation of DLK1 asan imprinted gene could contribute to human hepatocellularcarcinoma[].Carcinogenesis, 2007, 28:1094-1103.

[15]Suwanjunee S, Wongchana W, Palagaa T, et al.Inhibitionof gamma-seeretase affects proliferation of leukemia andhepatoma cell lines through Notch signaling[J].Anti-Canc-er Drugs, 2008, 19 (5) :477-486.

[16]Cantarini MC, Dela Monte SM, Pang M, et al.Asparagylhydroxylase over expression in human hepatoma is linked toactivation of insulin-like growth factor and Notch signalingmechanisms[J].Hepatology, 2006, 44 (2) :446-457.

[17]Noguera-TroiseⅠ, Daly C, Papadopoulos NJ, et al.Blockadeof Dl14 inhibits tumour growth by promoting non-productiveangiogenesi[J].Nature, 2006, 444 (7l22) :1032-1037.

[18]Liu J, Wang K, Shen F.Notch signal pathway and tumor[J].Acad J Sec Mil Med Univ, 2008, 29 (8) :975-978.

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