Role of “two-hit” in non-alcoholic fatty liver disease
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摘要: 非酒精性脂肪肝(NAFLD)是肝脏系统中一类最为普遍的肝脏疾病。近年来,随着生活水平的提高,其发病率也逐年上升。由于NAFLD发病的隐匿性,其具体的发病机制目前仍不清楚,"二次打击"学说在其中的重要地位已得到一致认可。现就NAFLD发病机制与"二次打击"相关的细胞因子、代谢以及免疫方面等因素作一综述。Abstract: The manifestation of non-alcoholic fatty liver disease (NAFLD) ranges from simple steatosis to non-alcoholic steatohepatitis.The "two-hit" hypothesis of NAFLD is widely accepted as an accurate description of the underlying pathogenic mechanism.The first hit is an increased fat flux to the liver, which predisposes a patient to the second hit, in which increased mitochondrial free fatty acid oxidation promotes oxidative stress, lipoperoxidation, and increased reactive oxygen species.In this review, we discuss the roles of immune-and inflammation-related factors, such as cytokines, and metabolic factors in the "two-hit" process of NAFLD.
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Key words:
- fatty liver /
- two-hit
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