人工肝血浆置换治疗重型肝炎的疗效观察

廖金卯; 李灼日; 胡小宣

人工肝血浆置换治疗重型肝炎的疗效观察

1. 湖南师范大学第一附属医院肝病内科
2. 海南省人民医院

基金项目:

湖南省科技厅支撑计划重点项目(2004sk2008)；

详细信息

中图分类号: R575.1
计量
- 文章访问数: 3580
- HTML全文浏览量: 14
- PDF下载量: 1548
- 被引次数: 0
出版历程
- 出版日期: 2012-04-20

The therapeutic effect of plasma exchange therapy in patients with severe hepatitis

Research funding:

摘要

摘要: 目的观察人工肝血浆置换治疗重型肝炎患者的临床疗效。方法 80例重型肝炎患者分为治疗组和对照组,治疗组在内科综合治疗的基础上进行血浆置换,对照组仅予以内科综合治疗,观察两组治疗前后的临床症状、体征和肝肾功能、凝血功能指标变化,并对预后进行分析,评价临床疗效。结果血浆置换治疗后,患者临床症状均有不同程度改善,肝肾功能及凝血酶原时间明显好转,与本组治疗前相比差异均有统计学意义(P<0.05或P<0.01),与对照组治疗后相比,除Alb外各指标差异均有统计学意义(P<0.05或P<0.01);治疗组总有效率为65.0%,其中早期治疗有效率为88.9%,与对照组比较差异均有统计学意义(P<0.05)。结论人工肝血浆置换是治疗重型肝炎的有效手段,对于早期患者疗效更好。
- 肝,人工 /
- 血浆置换 /
- 肝功能衰竭
Abstract: Objective To investigate the clinical therapeutic effect of artificial liver plasma exchange therapy in patients with severe hepatitis.Methods 80 patients with severe hepatitis were divided into treatment group and control group, the treatment group was treated with plasma exchange on the basis of synthetic internal comprehensive medical treatment, and the control group was treated with synthetic internal comprehensive medical treatment alone.clinical symptoms and signs, liver and kidney function, blood coagulation function index changes of the two groups were observed before and after the treatment, and prognosis was analyzed and clinical curative effect was evaluated.Results After plasma exchange treatment, clinical symptoms were improved at different degrees.Liver function, kidney function and prothrombin time of the treatment group were significantly improved, compared with the results before treatment (P<0.05 or P<0.01) , whereas in the control group after treatment, the indicators in addition to Alb were significantly different (P<0.05 or P<0.01) .The total effective rate of the treatment group was 65.0%, among which early treatment rate was 88.9%, compared with control group differences were significant (P<0.05) Conclusion Artificial liver plasma exchange is an effective means of treatment for severe hepatitis and it is better for early stage patients.
- liver /
- artificial /
- plasma exchange

HTML全文

参考文献(12)

[1]中华医学会传染病与寄生虫病学分会和肝脏学分会.病毒性肝炎防治指南[J].中华肝脏病杂志, 2000, 8 (6) :324-329.

[2] 传染病与寄生虫病学会人工肝学组.人工肝支持系统的适应证、禁忌证和疗效判断[J].中华肝脏病杂志, 2002, 10 (6) :405.

[3]O’GRADY JG.Acute liver failure[J].Postgrad Med J, 2005, 81 (953) :148-154.

[4]林世德, 罗亚文, 苏毅, 等.重型肝炎研究进展[J].实用肝脏病杂志, 2009, 12 (1) :73-75.

[5]Shito M, Balis UJ, Tompkins RG, et al.A fulminant hepaticfailure model in the rat:involvement of interleukin-1betaand tumor necrosis factor-alpha[J].DigDis Sci, 2001, 46 (8) :1700-1708.

[6]罗明, 曹武德.微生态调节剂治疗重型肝炎内毒素血症的研究进展[J].临床肝胆病杂志, 2011, 27 (7) :775-778.

[7]Nishimura A, Umehara Y, Umehara M, et al.Plasma ex-change-based plasma recycling dialysis system as a poten-tial platform for artificial liver support[J].Artif Organs, 2006, 30 (8) :629-633.

[8]Li LJ, Zhang YM, Liu XL, et al.Artificial liver support systemin China:a review over the last 30 years[J].Ther Apher Di-al, 2006, 10 (2) :160-167.

[9]吴锦瑜, 杜美英, 曹旺发.人工肝血浆置换术治疗早期重型肝炎疗效观察[J].临床肝胆病杂志, 2007, 23 (1) :53-54.

[10]徐少保, 高人焘, 沈强.血浆置换治疗重型肝炎的疗效评价[J].实用肝脏病杂志, 2008, 11 (5) , 305-306.

[11]Agishi T, Nakagawa Y, Terakoka S, et al.Plasm a exchangeas a rescue strategy for hepatic failure[J].ASAIO J, 1994, 40 (1) :77.

[12]Li N, Gao YF, Su F, et al.The value of MELD in the assess-ment of short-term prognosis of severe hepatitis by artificialliver treatment[J].Chin J Hepatol, 2011, 19 (6) :469-470.

施引文献

资源附件(0)

访问统计