PDF下载 ( 1085 KB)
A study on the role of serum Retinol Binding Protein 4 in nonalcoholic fatty liver disease
-
摘要: 目的探讨非酒精性脂肪性肝病（NAFLD）患者血清视黄醇结合蛋白4（RBP4）的临床意义。方法选择NAFLD肝患者62例,正常对照60例,采用ELISA方法测定空腹血清RBP4,同时检测其血糖、血脂、肝功能及胰岛素水平,并计算胰岛素抵抗指数（HOMA-IR）。结果与正常对照组比较,NAFLD患者的空腹血糖（FBG）、总胆固醇（TC）、甘油三酯（TG）、低密度酯蛋白（LDL-C）、血清胰岛素（FINS）、HOMA-IR、ALT、AST和RBP4显著增高（P<0.01）,而且NAFLD患者治疗后血清RBP4水平显著降低。相关分析显示,血清RBP4与FBG、TC、TG、FINS、HOMA-IR呈正相关。结论在NAFLD的发病过程中,RBP4可能参与其发病,在其早期诊断和评判肝脏损害程度中有一定的临床意义。
-
关键词:
- 非酒精性脂肪性肝病 /
- 视黄醇结合蛋白质类,血浆
Abstract: Objective To evaluate the role of serum retinol binding protein 4 (RBP4) in patients with nonalcoholic fatty liver disease (NAFLD) .Methods 62 patients with nonalcoholic fatty liver disease (NAFLD group) and 60 normal subjects (normal control group) were selected.The level of serum RBP4 was measured by ELISA.Fasting blood glucose (FBG) , blood lipid (TC, TG, HDL-C, LDL-C) , liver function (AST, ALT) , and fasting insulin (FINS) were measured.Homeostasis model assessment of insulin resistance (HOMA-IR) were calculated as well.Results The levels of RBP4, FBG, TC, TG, LDL-C, FINS, ALT, AST and HOMA-IR were higher in NAFLD patients as compared to normal controls (P<0.01) .The levels of Serum RBP4 were positively correlated with FBG, TC, TG, FINS and HOMA-IR (r=0.329, 0.298, 0.261, 0.219, 0.378, P<0.01) .Conclusion RBP4 was involved in the development of nonalcoholic fatty liver disease.Thus, RBP4 may be used as a sensitive indicator for the pathogenesis and the development of NAFLD, which can assist in early diagnosis of the disease.-
Key words:
- nonalcoholic fatty liver disease /
- retinol binding proteins
-
[1]中华医学会肝脏病学分会脂肪肝和酒精性肝病学组.非酒精性脂肪肝病诊疗指南[J].中华肝脏杂志, 2006, 14 (2) :161-163. [2]Yang Q, Graham TE, Mody N, et al.Serum retinol bindingprotein 4 contributes to insulin resistance in obesity and type2 diabetes[J].Nature, 2005, 436 (7049) :356-362. [3]Wu H, Jia W, Bao Y, et al.Serum retinol binding protein 4 andnonalcoholic fatty liver disease in patients with type 2 diabetes[J].Diabetes Res Clin Pract, 2008, 79 (2) :185-190. [4]Yan KK, Palmer CS, Lloyd AR, et al.Relationship of RetinolBinding Protein-4 with Liver Injury in Morbidly Obese Sub-jects[J].Hepatology, 2009, 50 (4) :S789A. [5]徐慧, 龚环宇, 陈丽敏, 等.视黄醇结合蛋白4在非酒精性脂肪肝病大鼠组织中的表达[J].现代生物医学进展, 2011, 11 (4) :642-645. [6]Seo JA, Kim NH, Park SY, et al.Serum retinol binding pro-tein 4 levels are elevated in non-alcoholic fatty liver disease[J].Clin Endocrinol, 2008, 68 (4) :555-560. -
本文二维码
计量
- 文章访问数: 2303
- HTML全文浏览量: 17
- PDF下载量: 621
- 被引次数: 0
下载:
