21世纪肝癌临床研究面临的挑战

汤钊猷

21世纪肝癌临床研究面临的挑战

汤钊猷

复旦大学附属中山医院肝癌研究所

详细信息

中图分类号: R735.7
计量
- 文章访问数: 2227
- HTML全文浏览量: 12
- PDF下载量: 784
- 被引次数: 0
出版历程
- 出版日期: 2012-04-20

21st century:challenges facing the clinical research of liver cancer

Tang ZhaoYou

摘要

摘要: <正>20世纪,建立在病理学基础上以消灭肿瘤为目标的战略,导致肝癌临床的重大进步,但距离攻克还有很大距离,为此21世纪仍面临重大挑战。1消灭肿瘤战略功不可没20世纪以消灭肿瘤为目标的疗法(手术、放化疗、局部治疗等)取得了有史以来最大的进步;早诊早治又进一步大幅度提高了疗效。美国肝癌人群的统计,
- 肝肿瘤
- liver neoplasms

HTML全文

参考文献(15)

[1]Jemal A, Bray F, Center MM, et al.Global cancer statistics[J].CA Cancer J Clin, 2011, 61 (2) :69-90.

[2]Liu L, Zhu XD, Wang WQ, et al.Activation of beta-cateninby hypoxia in hepatocellular carcinoma contributes to en-hanced metastatic potential and poor prognosis[J].ClinCancer Res, 2010, 16 (10) :2740-2750.

[3]Huang XY, Huang ZL, Wang L, et al.Herbal compound"Songyou Yin"reinforced the ability of interferon-alfa to in-hibit the enhanced metastatic potential induced by palliativeresection of hepatocellular carcinoma in nude mice[J].BMCCancer, 2010, 10:580.

[4]Ellis LM, Reardon DA.Is there really a yin and yang to VEGF-targeted therapies[J].Lancet Oncol, 2010, 11 (9) :809-811.

[5]Ye QH, Qin LX, Forgues M, et al.Predicting hepatitis B vi-rus-positive metastatic hepatocellular carcinomas usinggene expression profiling and supervised machine learning[J].Nat Med, 2003, 9 (4) :416-423.

[6]Shen YC, Hsu C, Chen LT, et al.Adjuvant interferon therapyafter curative therapy for hepatocellular carcinoma (HCC) :ameta-regression approach[J].J Hepatol, 2010, 52 (6) :889-894.

[7]Zhang XW, Yan XJ, Zhou ZR, et al.Arsenic trioxide controlsthe fate of the PML-RARalpha oncoprotein by directly bind-ing PML[J].Science, 2010, 328 (5975) :240-243.

[8]Grivennikov SI, Greten FR, Karin M.Immunity, inflamma-tion, and cancer[J].Cell, 2010, 140 (6) :883-899.

[9]Dinarello CA.Anti-inflammatory agents:present and future[J].Cell, 2010, 140 (6) :935-950.

[10]Jacobs EJ.Will an aspirin a day help keep fatal cancer away?[J].Lancet, 2011, 377 (9759) :3-4.

[11]Zhang W, Zhu XD, Sun HC, et al.Depletion of tumor-associ-ated macrophages enhances the effect of sorafenib in metastat-ic liver cancer models by antimetastatic and antiangiogeniceffects[J].Clin Cancer Res, 2010, 16 (13) :3420-3430.

[12]Hart GW, Copeland RJ.Glycomics hits the big time[J].Cell, 2010, 143 (5) :672-676.

[13]Thaker PH, Han LY, Kamat AA, et al.Chronic stress pro-motes tumor growth and angiogenesis in a mouse model ofovarian carcinoma[J].Nat Med, 2006, 12 (8) :939-944.

[14]Ondicova K, Mravec B.Role of nervous system in cancer aetio-pathogenesis[J].Lancet Oncol, 2010, 11 (6) :596-601.

[15]Xiong W, Ren ZG, Qiu SJ, et al.Residual hepatocellular car-cinoma after oxaliplatin treatment has increased metastaticpotential in a nude mouse model and is attenuated by Songy-ou Yin[J].BMC Cancer, 2010, 10:219.

施引文献

资源附件(0)

访问统计