载脂蛋白C-Ⅲ基因多态性的研究进展

张丁丁; 辛永宁; 徐静; 宣世英

载脂蛋白C-Ⅲ基因多态性的研究进展

1. 青岛大学医学院
2. 青岛市市立医院消化内二科
3. 中国海洋大学医药学院
4. 青岛市消化疾病重点实验室

详细信息

中图分类号: R346
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出版历程
- 出版日期: 2012-02-20

Research advance of the apolipoproteinC-Ⅲ polymorphisms

摘要

摘要: 载脂蛋白C-Ⅲ（APOC-Ⅲ）通过抑制脂蛋白酶而调节体内脂质代谢。APOC-Ⅲ基因的多态性变化会影响APOC-Ⅲ蛋白的表达与功能,引起体内脂质代谢的改变。研究比较深入的APOC-Ⅲ基因多态性位点是位于3’端非编码区的3238C>G（即SstI多态性）,位于启动子区胰岛素反应元件上的-482C>T和-455T>C,它们与代谢综合征（MS）、冠心病（CAD）、非酒精性脂肪性肝病（NAFLD）密切相关。本综述旨在总结前人的研究成果,为今后的工作发现新思路。
- 载脂蛋白C-Ⅲ /
- 基因多态性 /
- 代谢综合征 /
- 冠心病 /
- 脂肪肝,非酒精性
Abstract: ApolipoproteinC-Ⅲ (APOC-Ⅲ) can affect lipid metabolism through inhibition of lipoprotein lipase (LPL) .Polymorphisms in the APOC-Ⅲ gene may affect the expression and function of the protein, thereafter interfering the lipid metabolism.The most famous single nucleotide polymorphisms (SNPs) are 3238C>G polymorphism (SstI site) in the 3'untranslated region, -482C>T and-455T>C polymorphisms in the insulin response element (IRE) of the promoter.There are strong associations between APOC-Ⅲ gene variants and diseases such as metabolic syndrome (MS) , coronary artery disease (CAD) and nonalcoholic fatty liver disease (NAFLD) .This review aims to summarize achievements and explore new ways for our future work.
- apolipoproteinC-Ⅲ /
- gene polymorphism /
- metabolic syndrome /
- coronary disease /
- fatty liver

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参考文献(33)

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