Abstract: Objective To analyse the clinical features and prognosis of 79 patients with subacute liver failure, and evaluate the efficacy of several special therapies.Methods We collected 79 cases of subacute liver failure in Beijing ditan hospital during 2004-2010, and retrospectively analysed the gender, age, etiology, complication, treatment and outcome.Results 60 cases of these patients were male while 19 were female.The mean age was 47.59 ±19.01 years old.The most common etiology was HEV infection (43.04%) , followed by HBV infection (27.85%) .The most common complications were ascites, celiac infection, hepatic encephalopathy, hepatorenal syndrome and hepatic encephalopathy were significantly associated with death.The mortality of these cases was 18.99%.Conclusion Subacute liver failure is more likely to occur in men and people over 40 years old, with a high mortality.HEV is the most common etiology of subacute liver failure.Ascites and celiac infection are the most common complications, while hepatorenal syndrome is the most common cause of death.