PDF下载 ( 1208 KB)
A clinical observation on metadoxine combined with tiopronin in the treatment of patients with alcoholic liver disease
-
摘要: 目的观察美他多辛联合硫普罗宁治疗酒精性肝病的疗效。方法 60例酒精性肝病住院患者随机分为治疗组和对照组各30例,两组一般治疗相同,对照组用硫普罗宁,治疗组在对照组基础上加用美他多辛片。治疗前后分别查TBil、ALT、AST、GGT、A/G、TC、TG等生化指标,并记录临床症状和体征变化。结果 4周后,治疗组总有效率96.67%,明显高于对照组的76.67%;治疗组治疗后的TBil、ALT、AST、GGT、A/G、TC、TG水平明显低于对照组,差异均有统计学意义(P<0.01)。两组在治疗期间均无明显不良反应。结论美他多辛和硫普罗宁联用疗效优于单用硫普罗宁。Abstract: Objective To evaluate the efficiency of metadoxine combined with tiopronin in the treatment of patients with alcoholic liver disease. Methods 60 cases of hospitalized patients with alcoholic liver disease were randomly divided into treatment group and control group with 30 cases in each group. The two groups received the same general treatment, and the control group was treated with tiopronin while the treatment group was added with metadoxine tablets based on the treatment of the control group.The TBil, ALT, AST, GGT, A/G, TC, TG and other biochemical indices were detected before and after treatment respectively, and the clinical symptoms and signs were observed. Results After 4 weeks, the total treatment efficiency was 96.67% in treatment group, which was significantly higher than that in control group 76.67%; after treatment the TBil, ALT, AST, GGT, A/G, TC, TG levels were significantly lower in treatment group than those in the control group, the difference was statistically significant (P<0.01) . There was no obvious adverse reaction in both the two groups. Conclusion Metadoxine and tiopronin combined treatment shows better effect than the single treatment with tiopronin.
-
Key words:
- liver disease /
- alcoholic /
- tiopronin
-
[1]中华医学会.酒精性肝病诊断标准[J].中华肝脏病杂志, 2001, 9 (5) :264. [2] 戴德银.实用新药物手册[M].北京:人民军医出版社, 2002:845-847. [3]Gutierrez-Ruiz MC, Bucio L, Correa A, et al.Metadoxineprevent damage produced by ethanol and acetaldehyde inhepatocyte and hepatic stellate cells in culture[J].Pharma-col Res, 2001, 44 (4) :431-436. [4]Diaz Martinez MC, Diaz Martinez A, Villamil Salcedo V, et al.Efficacy of metadoxine in the management of acute alcoholintoxication[J].J Int Med Res, 2002, 30 (1) :44-51. [5]Shpilenya LS, Muzychenko AP, Gasbarrini G, et al.Meta-doxine in acute alcohol intoxication:a double-blind, ran-domized, placebo-controlled study[J].Alcohol Clin ExpRes, 2002, 26 (3) :340-346. [6]Addolorato G, Ancona C, Capristo E, et al.Metadoxine inthe treatment of acute and chronic alcoholism:a review[J].Int J Immunopathol Pharmacol, 2003, 16 (3) :207-214. [7]杨卫红.还原型谷胱甘肽联合硫普罗宁治疗药物性肝炎43例的疗效观察[J].广东医学院学报, 2006, 24 (6) :621-622. [8]张武汉.硫普罗宁治疗酒精性肝炎56例[J].实用肝脏病杂志, 2006, 9 (4) :235. [9]吕明磊, 刘琴, 李旭东, 等.硫普罗宁注射剂与HD-91-Ⅱ型肝病治疗仪联合治疗脂肪肝临床观察[J].医学信息手术学分册, 2007, 20 (4) :327-328. [10]汪索文, 周世庆, 张伯新, 等.美他多辛治疗酒精性肝病的疗效观察[J].中国全科医学, 2005, 8 (10) :835. [11]茅益民, 曾民德, 陆伦根, 等.美他多辛治疗酒精性肝病的多中心、随机、双盲、安慰剂平行对照临床研究[J].肝脏, 2006, 11 (5) :303-306. -
本文二维码
计量
- 文章访问数: 3656
- HTML全文浏览量: 14
- PDF下载量: 662
- 被引次数: 0
下载:
