Abstract: Objective To analyze the clinical data of 218 in-patients with alcoholic liver disease (ALD) in the First Affiliated Hospital of Dalian Medical University between 2000 and 2010, and to study the clinical characteristics and risk factors. Methods The clinical data of 218 patients with ALD were analyzed statistically, which included history of alcohol intake, clinical manifestations, liver function tests and radiology results and so on. Results The morbidity of ALD, especially alcoholic liver cirrhosis is increasing annually with the peak incidence occurring in the age group from 21 to 40 years old. AC group have longer drinking duration than that of AFL group and AH group, and there is significant difference among the three groups. Analysis of variance is used to compare level of AST, ALT, AST/ALT, GGT, ALP, A/G, TBil and TC among AFL, AH and AC group, and their statistical difference is significant. Conclusion The severity and prognosis of ALD may be related to the long-term alcohol abuse history (including the amount and duration of drinking) . There is a tendency to increase annually and younger patients are more affected. AST/ALT, GGT, ALP, A/G, TBil, TG and CHOL should be detected periodically in patients with alcohol addiction in order to diagnose and treat earlier, to improve their prognosis.