慢性乙型肝炎肝内胆汁淤积性黄疸发病机制的研究概况

杨宗国; 陈晓蓉; 刘成

慢性乙型肝炎肝内胆汁淤积性黄疸发病机制的研究概况

上海市公共卫生临床中心

基金项目:

中医药防治艾滋病、病毒性肝炎等疾病临床科研一体化技术平台体系构建及应用研究(2009ZX10005-019)；

详细信息

中图分类号: R714.2
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出版历程
- 出版日期: 2011-12-20

The research advancement of pathogenesis of intrahepatic cholestasis jaundice related to chronic hepatits B

Research funding:

摘要

摘要: 慢性乙型肝炎致肝内胆汁淤积性黄疸的发病机制极其复杂,其中肝细胞凋亡、氧化应激及脂质过氧化、巨噬细胞介导的炎症反应等途径均参与肝内胆汁淤积性黄疸的发病。明确肝内胆汁淤积性黄疸的发病机制对临床靶点治疗有重要意义。
- 肝炎,乙型,慢性 /
- 胆汁淤积,肝内 /
- 细胞凋亡
Abstract: The pathogenesis of intrahepatic cholestasis jaundice caused by chronic hepatits B is extremely complicated, and the following pathways such as hepatocytes apoptosis, oxidative stress, lipid peroxidation and inflammatory response mediated by macrophage have a close link with the pathogenesis of intrahepatic cholestasis jaundice.To have a clear and complete definition on the pathogenesis of intrahepatic cholestasis jaundice is of great significance for its clinical target therapy.
- hepatitis B /
- chronic /
- cholestasis

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参考文献(30)

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