HBV mother-to-child transmission block-agreement and controversy
-
摘要: 慢性乙型肝炎因其严重的不良临床结局如肝硬化或肝细胞癌而成为严重的公共卫生问题,而母婴传播是导致慢性HBV感染的最主要原因。尽管HBV阳性孕妇所生的新生儿在出生后24 h之内应用了乙型肝炎疫苗和乙型肝炎免疫球蛋白(HBIG)进行联合免疫阻断,仍然有大约10%左右的新生儿感染了HBV,特别是高病毒载量的孕妇。本文将就HBV母婴传播的特点、目前在阻断措施方面达成的共识和存在的争议进行论述。Abstract: Hepatitis B virus (HBV) infection is one of the most severe public issue due to its serious harmful clinical outcomes such as cirrhosis or HCC.The mother-to-child transmission (MTCT, vertical transmission) is the main cause leading to chronic HBV infections.Though joint HBV immune prophylaxis with hepatitis B vaccine and hepatitis B immunoglobulin (HBIG) are given within 24hrs after birth for all neonates whose mothers are HBV positive, about 10% of them suffer from HBV infection in their early life, even in pregnant women with a high HBV DNA serum load.This paper discusses the thesis concerning on agreement and controversy regarding the MTCT.
-
Key words:
- hepatitis B chronic /
- hepatitis B virus /
- disease transmission
-
[1]European Association for the Study of the Liver.EASL Clini-cal Practice Guidelines:Management of chronic hepatitis B[J].J Hepatol, 2009, 50:227-242. [2]Petrova M, Kamburov V.Breastfeeding and chronic HBV in-fection:Clinical and social implications[J].World J Gastro-enterol, 2010, 16 (40) :5042-5046. [3] Shi Z, Li X, Ma L, et al. Hepatitis B immunoglobulin injection in pregnancy to interrupt hepatitis B virus mother-to-child transmission-a meta-analysis[J]. Int J Infect Dis, 2010, 14 (7) : e622-634. [4]Shao ZJ, Zhang L, Xu JQ, et al.Mother-to-infant trans-mission of hepatitis B virus:a Chinese experience[J].JMed Virol, 2011, 83 (5) :791-795. [5]Shi Z, Yang Y, Ma L, et al.Lamivudine in late pregnancy tointerrupt in utero transmission of hepatitis B virus:a system-atic review and meta-analysis[J].Obstet Gynecol, 2010, 116 (1) :147-159. [6]Xu WM, Cui YT, Wang L, et al.Lamivudine in late pregnan-cy to prevent perinatal transmission of hepatitis B virus infec-tion:a multicentre, randomized, double-blind, placebo-controlled study[J].J Viral Hepat, 2009, 16 (2) :94-103. [7]van Zonneveld M, van Nunen AB, Niesters HG, et al.Lami-vudine treatment during pregnancy to prevent perinatal trans-mission of hepatitis B virus infection[J].J Viral Hepat, 2003, 10 (4) :294-297. [8]Wiseman S, D'Souza S, Kostkova P, et al.A Year on-Na-tional Resource for Infection Control[J].J Hosp Infect, 2006, 63 (Suppl 1) :S6y1. [9]Elefsiniotis IS, Tsoumakas K, Papadakis M, et al.Importance ofmaternal and cord blood viremia in pregnant women with chron-ic hepatitis B virus infection[J].Eur J Intern Med, 2011, 22 (2) :182-186.
本文二维码
计量
- 文章访问数: 3353
- HTML全文浏览量: 17
- PDF下载量: 873
- 被引次数: 0