慢性乙型肝炎的疗效预测和优化治疗策略

樊蓉; 孙剑; 侯金林

慢性乙型肝炎的疗效预测和优化治疗策略

南方医科大学南方医院肝病中心和感染内科

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中图分类号: R512.62
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出版历程
- 收稿日期: 2011-10-19
- 出版日期: 2011-12-20

Predictors of response and optimized antiviral strategy for patients with chronic hepatitis B

摘要

摘要: 乙型肝炎抗病毒治疗的药物包括两大类:α-干扰素类和核苷（酸）类似物。目前临床抗病毒方案存在疗效不佳和耐药率高的缺点,而探索预测疗效的指标,并在此基础上优化抗病毒治疗方案提高疗效,降低耐药率成为我国乙型肝炎临床研究的重点。抗病毒药物优化的关键就在于:在适当的时机选择合适的抗病毒药物,并在治疗过程中监测应答情况,对疗效欠佳的患者及时调整治疗方案,以提高远期疗效,降低耐药的发生。在中国制定一套适合我国国情的抗病毒优化治疗策略将是我国乙型肝炎治疗领域亟待解决的重要问题之一。
- 肝炎,乙型,慢性 /
- 干扰素α /
- 核酸类,核苷酸和核苷类
Abstract: There are two kinds of approved anti-hepatitis B virus agents including interferons and nucleos (t) ide analogues.Effort should be made to improve the antiviral efficacy and to reduce the risk of viral resistance due to poor response of current antiviral strategy, depending on exploring the predictors of response.The point of optimized antiviral strategy is to initiate treatment with a proper drug at the proper timepoint, to monitor the on-treatment response closely and, in the patients with poor response, to consider adding on a second drug or switching to another more potent drug.Optimization of antiviral strategy for chronic hepatitis B patients, which is suitable for China, is one of the important issues to be resolved.
- hepatitis B /
- chronic /
- interferon-alpha

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参考文献(26)

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