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慢性胰腺炎的危险因素分析

窦维佳 周林 吴开春

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慢性胰腺炎的危险因素分析

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  • 中图分类号: R576

Risk factors of chronic pancreatitis

  • 摘要: 慢性胰腺炎病因复杂。近年来针对慢性胰腺炎的流行病学研究发现,慢性胰腺炎发病率逐年升高且病因构成发生改变。酒精虽然仍是导致慢性胰腺炎最常见的危险因素,但其比例显著下降,酒精摄入量与慢性胰腺炎的患病风险密切相关。长期吸烟也被认为是慢性胰腺炎相关的独立危险因素。其他病因如遗传性、自身免疫性及特发性慢性胰腺炎等发病率较前增加。在我国,酒精已超越胆道疾病成为慢性胰腺炎的主要病因。

     

  • [1]Frulloni L, Gabbrielli A, Pezzilli R, et al.Chronic pancreatitis:report from a multicenter Italian survey (PanCroInfAISP) on893 patients[J].Dig Liver Dis, 2009, 41 (4) :311-317.
    [2]Yadav D, Whitcomb DC.The role of alcohol and smoking inpancreatitis[J].Nat Rev Gastroenterol Hepatol, 2010, 7 (3) :131-145.
    [3]王洛伟, 李兆申, 李淑德, 等.慢性胰腺炎全国多中心流行病学调查[J].胰腺病学, 2007, 7 (1) :1-5.
    [4]Cote GA, Yadav D, Slivka A, et al.Alcohol and smoking asrisk factors in an epidemiology study of patients with chronicpancreatitis[J].Clin Gastroenterol Hepatol, 2011, 9 (3) :266-273, e27.
    [5]Witt H, Apte MV, Keim V, et al.Chronic pancreatitis:chal-lenges and advances in pathogenesis, genetics, diagnosis, and therapy[J].Gastroenterology, 2007, 132 (4) :1557-1573.
    [6]Yadav D, Hawes RH, Brand RE, et al.Alcohol consumption, cigarette smoking, and the risk of recurrent acute and chronicpancreatitis[J].Arch Intern Med, 2009, 169 (11) :1035-1045.
    [7]Kristiansen L, Gronbaek M, Becker U, et al.Risk of pancre-atitis according to alcohol drinking habits:a population-based cohort study[J].Am J Epidemiol, 2008, 168 (8) :932-937.
    [8]Yadav D, Slivka A, Sherman S, et al.Smoking is underrec-ognized as a risk factor for chronic pancreatitis[J].Pancre-atology, 2010, 10 (6) :713-719.
    [9]Tolstrup JS, Kristiansen L, Becker U, et al.Smoking andrisk of acute and chronic pancreatitis among women andmen:a population-based cohort study[J].Arch InternMed, 2009, 169 (6) :603-609.
    [10]Andriulli A, Botteri E, Almasio PL, et al.Smoking as a cofac-tor for causation of chronic pancreatitis:a meta-analysis[J].Pancreas, 2010, 39 (8) :1205-1210.
    [11]Maisonneuve P, Lowenfels AB, Mullhaupt B, et al.Ciga-rette smoking accelerates progression of alcoholic chronicpancreatitis[J].Gut, 2005, 54 (4) :510-514.
    [12]Katz M, Carangelo R, Miller LJ, et al.Effect of ethanol oncholecystokinin-stimulated zymogen conversion in pancreat-ic acinar cells[J].Am J Physiol, 1996, 270 (1 Pt 1) :G171-G175.
    [13]Pandol SJ, Periskic S, Gukovsky I, et al.Ethanol diet increa-ses the sensitivity of rats to pancreatitis induced by cholecys-tokinin octapeptide[J].Gastroenterology, 1999, 117 (3) :706-716.
    [14]Lu Z, Karne S, Kolodecik T, et al.Alcohols enhance caer-ulein-induced zymogen activation in pancreatic acinar cells[J].Am J Physiol Gastrointest Liver Physiol, 2002, 282 (3) :G501-G507.
    [15]Apte MV, Phillips PA, Fahmy RG, et al.Does alcohol direct-ly stimulate pancreatic fibrogenesis?Studies with rat pancre-atic stellate cells[J].Gastroenterology, 2000, 118 (4) :780-794.
    [16]Bachem MG, Zhou Z, Zhou S, et al.Role of stellate cells inpancreatic fibrogenesis associated with acute and chronicpancreatitis[J].J Gastroenterol Hepatol, 2006, 21 (Suppl3) :S92-S96.
    [17]Comfort MW, Steinberg AG.Pedigree of a family with he-reditary chronic relapsing pancreatitis[J].Gastroenterology, 1952, 21 (1) :54-63.
    [18]Le Bodic L, Bignon JD, Raguenes O, et al.The hereditarypancreatitis gene maps to long arm of chromosome 7[J].Hum Mol Genet, 1996, 5 (4) :549-554.
    [19]Whitcomb DC, Gorry MC, Preston RA, et al.Hereditary pan-creatitis is caused by a mutation in the cationic trypsinogengene[J].Nat Genet, 1996, 14 (2) :141-145.
    [20]Teich N, Mossner J.Hereditary chronic pancreatitis[J].BestPract Res Clin Gastroenterol, 2008, 22 (1) :115-130.
    [21]Ooi CY, Dorfman R, Cipolli M, et al.Type of CFTR mutationdetermines risk of pancreatitis in patients with cystic fibrosis[J].Gastroenterology, 2011, 140 (1) :153-161.
    [22]Schneider A, Larusch J, Sun X, et al.Combined bicarbonate conductance-impairing variants in CFTR and SPINK1 vari-ants are associated with chronic pancreatitis in patients with-out cystic fibrosis[J].Gastroenterology, 2011, 140 (1) :162-171.
    [23]Finkelberg DL, Sahani D, Deshpande V, et al.Autoimmunepancreatitis[J].N Engl J Med, 2006, 355 (25) :2670-2676.
    [24]Keller J, Layer P.Idiopathic chronic pancreatitis[J].BestPract Res Clin Gastroenterol, 2008, 22 (1) :105-113.
    [25]Castellani C, Lira MG, Frulloni L, et al.Analysis of the entirecoding region of the cystic fibrosis transmembrane regulatorgene in idiopathic pancreatitis[J].Hum Mutat, 2001, 18 (2) :166.
    [26]Cohn JA, Friedman KJ, Noone PG, et al.Mutations of thecystic fibrosis gene, but not cationic trypsinogen gene, areassociated with recurrent or chronic idiopathic pancreatitis[J].Am J Gastroenterol, 2000, 95 (8) :2061-2067.
    [27]Sharer N, Schwarz M, Malone G, et al.Mutations of thecystic fibrosis gene in patients with chronic pancreatitis[J].N Engl J Med, 1998, 339 (10) :645-652.
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  • 收稿日期:  2011-10-19
  • 出版日期:  2011-11-20
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