The role of high mobility group box 1 in human liver diseases
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摘要: 高迁移率族蛋白B1(HMGB1)是含量丰富的非组蛋白染色体结合蛋白,在细胞损伤和炎症反应时可通过主动分泌和被动释放移位到细胞浆和细胞外。近年研究提示HMGBl可作为一种炎症因子和内源性损伤相关分子模式被其受体识别而促进肝脏炎症、损伤和纤维化发生信号,并参与肝脏肿瘤发生和对肿瘤的免疫反应。本文对这些方面的研究进展作一简要综述。Abstract: High mobility group box 1 (HMGB1) is an enriched non-histone, chromatin-associated nuclear protein.During cell damage and inflammation HMGB1 can be extracellularly released by ways of active secretion and passive diffusion.Recent studies shows that HMGB1 may act as an inflammatory factor and an endogenous damage-associated molecular pattern recognized by its receptors, mediates liver inflammation, injury, fibrogenesis, as well as oncogenesis and tumor immune response.This review introduces the structure, function of HMGB1 and its role in human liver diseases.
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Key words:
- liver diseases /
- HMGB1 protein
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[1]Park JS, Svetkauskaite D, He Q, et al.Involvement of toll-like receptors 2 and 4 in cellular activation by high mobilitygroup box 1 protein[J].J Biol Chem, 2004, 279 (9) :7370-7377. [1]Park JS, Svetkauskaite D, He Q, et al.Involvement of toll-like receptors 2 and 4 in cellular activation by high mobilitygroup box 1 protein[J].J Biol Chem, 2004, 279 (9) :7370-7377. [2]Guo JS, Friedman SL.Toll-like receptor 4 signaling in liverinjury and hepatic fibrogenesis[J].Fibogenesis Tissue Re-pair, 2010, 3:21. [2]Guo JS, Friedman SL.Toll-like receptor 4 signaling in liverinjury and hepatic fibrogenesis[J].Fibogenesis Tissue Re-pair, 2010, 3:21. [3]Goodwin GH, Sanders C, Johns EW.A new group of chromatin-associated proteins with a high content of acidic and basic a-mino acids[J].Eur J Biochem, 1973, 38 (1) :14-19. [3]Goodwin GH, Sanders C, Johns EW.A new group of chromatin-associated proteins with a high content of acidic and basic a-mino acids[J].Eur J Biochem, 1973, 38 (1) :14-19. [4]Suda K, Takeuchi H, Ishizaka A, et al.High mobility groupbox chromosomal protein 1 as a new target for modulatingstress response[J].Surg Today, 2010, 40 (7) :592-601. [4]Suda K, Takeuchi H, Ishizaka A, et al.High mobility groupbox chromosomal protein 1 as a new target for modulatingstress response[J].Surg Today, 2010, 40 (7) :592-601. [5]Tang D, Kang R, Zeh III HJ 3rd, et al.High mobility groupbox 1, oxidative stress, and disease[J].Antioxid RedoxSignal, 2011, 14 (7) :1315-1335. [5]Tang D, Kang R, Zeh III HJ 3rd, et al.High mobility groupbox 1, oxidative stress, and disease[J].Antioxid RedoxSignal, 2011, 14 (7) :1315-1335. [6]Wang H, Bloom O, Zhang M, et al.HMG-1 as a late medi-ator of endotoxin lethality in mice[J].Science, 1999, 285 (5425) :248-251. [6]Wang H, Bloom O, Zhang M, et al.HMG-1 as a late medi-ator of endotoxin lethality in mice[J].Science, 1999, 285 (5425) :248-251. [7]Yang H, Ochani M, Li J, et al.Reversing established sepsiswith antagonists of endogenous high-mobility group box 1[J].Proc Natl Acad Sci U S A, 2004, 101 (1) :296-301. [7]Yang H, Ochani M, Li J, et al.Reversing established sepsiswith antagonists of endogenous high-mobility group box 1[J].Proc Natl Acad Sci U S A, 2004, 101 (1) :296-301. [8]张婷, 夏敏.高迁移率族蛋白B1信号转导通路的研究进展[J].医学综述, 2011, 17 (2) :195-198. [8]张婷, 夏敏.高迁移率族蛋白B1信号转导通路的研究进展[J].医学综述, 2011, 17 (2) :195-198. [9]Scaffidi P, Misteli T, Bianchi ME.Release of chromatin pro-tein HMGB1 by necrotic cells triggers inflammation[J].Na-ture, 2002, 418 (6894) :191-195. [9]Scaffidi P, Misteli T, Bianchi ME.Release of chromatin pro-tein HMGB1 by necrotic cells triggers inflammation[J].Na-ture, 2002, 418 (6894) :191-195. [10]Semino C, Angelini G, Poggi A, et al.NK/iDC interaction re-sults in IL-18 secretion by DCs at the synaptic cleft followedby NK cell activation and release of the DC maturation factorHMGB1[J].Blood, 2005, 106 (2) :609-616. [10]Semino C, Angelini G, Poggi A, et al.NK/iDC interaction re-sults in IL-18 secretion by DCs at the synaptic cleft followedby NK cell activation and release of the DC maturation factorHMGB1[J].Blood, 2005, 106 (2) :609-616. [11]Bonaldi T, Talamo F, Scaffidi P, et al.Monocytic cells hy-peracetylate chromatin protein HMGB1 to redirect it towardssecretion[J].EMBO J, 2003, 22 (20) :5551-5560. [11]Bonaldi T, Talamo F, Scaffidi P, et al.Monocytic cells hy-peracetylate chromatin protein HMGB1 to redirect it towardssecretion[J].EMBO J, 2003, 22 (20) :5551-5560. [12]Dumitriu IE, Baruah P, Manfredi AA, et al.HMGB1:guidingimmunity from within[J].Trends Immunol, 2005, 26 (7) :381-387. [12]Dumitriu IE, Baruah P, Manfredi AA, et al.HMGB1:guidingimmunity from within[J].Trends Immunol, 2005, 26 (7) :381-387. [13]Park JS, Arcaroli J, Yum HK, et al.Activation of gene ex-pression in human neutrophils by high mobility group box 1protein[J].Am J Physiol Cell Physiol, 2003, 284 (4) :C870-879. [13]Park JS, Arcaroli J, Yum HK, et al.Activation of gene ex-pression in human neutrophils by high mobility group box 1protein[J].Am J Physiol Cell Physiol, 2003, 284 (4) :C870-879. [14]Palumbo R, Galvez BG, Pusterla T, et al.Cells migrating tosites of tissue damage in response to the danger signalHMGB1 require NF-kappaB activation[J].J Cell Biol, 2007, 179 (1) :33-40. [14]Palumbo R, Galvez BG, Pusterla T, et al.Cells migrating tosites of tissue damage in response to the danger signalHMGB1 require NF-kappaB activation[J].J Cell Biol, 2007, 179 (1) :33-40. [15]Yang D, Chen Q, Yang H, et al.High mobility group box-1protein induces the migration and activation of human den-dritic cells and acts as an alarmin[J].J Leukoc Biol, 2007, 81 (1) :59-66. [15]Yang D, Chen Q, Yang H, et al.High mobility group box-1protein induces the migration and activation of human den-dritic cells and acts as an alarmin[J].J Leukoc Biol, 2007, 81 (1) :59-66. [16]Tsung A, Klune JR, Zhang X, et al.HMGB1 release inducedby liver ischemia involves Toll-like receptor 4 dependent re-active oxygen species production and calcium-mediated sig-naling[J].J Exp Med, 2007, 204 (12) :2913-2923. [16]Tsung A, Klune JR, Zhang X, et al.HMGB1 release inducedby liver ischemia involves Toll-like receptor 4 dependent re-active oxygen species production and calcium-mediated sig-naling[J].J Exp Med, 2007, 204 (12) :2913-2923. [17]Park JS, Gamboni-Robertson F, He Q, et al.High mobilitygroup box 1 protein interacts with multiple Toll like receptors[J].Am J Physiol Cell Physiol, 2006, 290 (3) :C917-C924. [17]Park JS, Gamboni-Robertson F, He Q, et al.High mobilitygroup box 1 protein interacts with multiple Toll like receptors[J].Am J Physiol Cell Physiol, 2006, 290 (3) :C917-C924. [18]Tsung A, Sahai R, Tanaka H, et al.The nuclear factorHMGB1 mediates hepatic injury after murine liver ischemia-reperfusion[J].J Exp Med, 2005, 201 (7) :1135-1143. [18]Tsung A, Sahai R, Tanaka H, et al.The nuclear factorHMGB1 mediates hepatic injury after murine liver ischemia-reperfusion[J].J Exp Med, 2005, 201 (7) :1135-1143. [19]Liu A, Dirsch O, Fang H, et al.HMGB1 in ischemic and non-ischemic liver after selective warm ischemia/reperfusion inrat[J].Histochem Cell Biol, 2011, 135 (5) :443-452. [19]Liu A, Dirsch O, Fang H, et al.HMGB1 in ischemic and non-ischemic liver after selective warm ischemia/reperfusion inrat[J].Histochem Cell Biol, 2011, 135 (5) :443-452. [20]Zhou RR, Zhao SS, Zou MX, et al.HMGB1 cytoplasmictranslocation in patients with acute liver failure[J].BMCGastroenterol, 2011, 11:21. [20]Zhou RR, Zhao SS, Zou MX, et al.HMGB1 cytoplasmictranslocation in patients with acute liver failure[J].BMCGastroenterol, 2011, 11:21. [21]刘洪波.乙型肝炎患者血清高迁移率族蛋白-1含量的检测及临床意义[J].中华肝脏病杂志, 2007, 15 (11) :812-814. [21]刘洪波.乙型肝炎患者血清高迁移率族蛋白-1含量的检测及临床意义[J].中华肝脏病杂志, 2007, 15 (11) :812-814. [22]Albayrak A, Uyanik MH, Cerrah S, et al.Is HMGB1 a newindirect marker for revealing fibrosis in chronic hepatitis and anew therapeutic target in treatment?[J].Viral Immunol, 2010, 23 (6) :633-638. [22]Albayrak A, Uyanik MH, Cerrah S, et al.Is HMGB1 a newindirect marker for revealing fibrosis in chronic hepatitis and anew therapeutic target in treatment?[J].Viral Immunol, 2010, 23 (6) :633-638. [23]Li L, Chen L, Hu L, et al.Nuclear factor high-mobilitygroup box1 mediating the activation of toll-like receptor 4signaling in hepatocytes in the early stage of nonalcoholic fat-ty liver disease in mice[J].Hepatology, 2011, Jul 11.doi:10.1002/hep.24552.[Epub ahead of print] [23]Li L, Chen L, Hu L, et al.Nuclear factor high-mobilitygroup box1 mediating the activation of toll-like receptor 4signaling in hepatocytes in the early stage of nonalcoholic fat-ty liver disease in mice[J].Hepatology, 2011, Jul 11.doi:10.1002/hep.24552.[Epub ahead of print] [24]Martin-Murphy BV, Holt MP, Ju C.The role of damage as-sociated molecular pattern molecules in acetaminophen-in-duced liver injury in mice[J].Toxicology Letter, 2010, 192 (3) :387-394. [24]Martin-Murphy BV, Holt MP, Ju C.The role of damage as-sociated molecular pattern molecules in acetaminophen-in-duced liver injury in mice[J].Toxicology Letter, 2010, 192 (3) :387-394. [25]Dragomir AC, Laskin JD, Laskin DL.Macrophage activationby factors released from acetaminophen-injured hepato-cytes:potential role of HMGB1[J].Toxicol Appl Pharma-col, 2011, 253 (3) :170-177. [25]Dragomir AC, Laskin JD, Laskin DL.Macrophage activationby factors released from acetaminophen-injured hepato-cytes:potential role of HMGB1[J].Toxicol Appl Pharma-col, 2011, 253 (3) :170-177. [26]Cheng BQ, Jia CQ, Liu CT, et al.Serum high mobility groupbox chromosomal protein 1 is associated with clinicopatho-logic features in patients with clinicopathologic features in pa-tients with hepatocellular carcinoma[J].Dig Liv Dis, 2008, 40 (6) :446-452. [26]Cheng BQ, Jia CQ, Liu CT, et al.Serum high mobility groupbox chromosomal protein 1 is associated with clinicopatho-logic features in patients with clinicopathologic features in pa-tients with hepatocellular carcinoma[J].Dig Liv Dis, 2008, 40 (6) :446-452. [27]王瀚锋, 徐晓东.高迁移率族蛋白B1肿瘤免疫调节作用及其机制[J].第二军医大学学报, 2010, 31 (12) :1359-1362. [27]王瀚锋, 徐晓东.高迁移率族蛋白B1肿瘤免疫调节作用及其机制[J].第二军医大学学报, 2010, 31 (12) :1359-1362. [28]Tang D, Kang R, Zeh HJ, et al.High-mobility group box 1and cancer[J].Biochim Biophys Acta, 2010, 1799 (1-2) :131-140. [28]Tang D, Kang R, Zeh HJ, et al.High-mobility group box 1and cancer[J].Biochim Biophys Acta, 2010, 1799 (1-2) :131-140. [29]Liang X, Chavez AR, Schapiro NE, et al.Ethyl pyruvate ad-ministration inhibits hepatic tumor growth[J].J Leukoc Bi-ol, 2009, 86 (3) :599-607. [29]Liang X, Chavez AR, Schapiro NE, et al.Ethyl pyruvate ad-ministration inhibits hepatic tumor growth[J].J Leukoc Bi-ol, 2009, 86 (3) :599-607. [30]Apetoh L, Ghiringhelli F, Tesniere A, et al.The interactionbetween HMGB1 and TLR4 dictates the outcome of antican-cer chemotherapy and radiotherapy[J].Immunol Rev, 2007, 220 (1) :47-59. [30]Apetoh L, Ghiringhelli F, Tesniere A, et al.The interactionbetween HMGB1 and TLR4 dictates the outcome of antican-cer chemotherapy and radiotherapy[J].Immunol Rev, 2007, 220 (1) :47-59. [31]Apetoh L, Ghiringhelli F, Tesniere A, et al.Toll-like recep-tor 4-dependent contribution of the immune system to anti-cancer chemotherapy and radiotherapy[J].Nat Med, 2007, 13 (9) :1050-1059. [31]Apetoh L, Ghiringhelli F, Tesniere A, et al.Toll-like recep-tor 4-dependent contribution of the immune system to anti-cancer chemotherapy and radiotherapy[J].Nat Med, 2007, 13 (9) :1050-1059. [32]Klune JR, Dhupar R, Cardinal J, et al.HMGB1:endogenousdanger signaling[J].Mol Med, 2008, 14 (7-8) :476-484. [32]Klune JR, Dhupar R, Cardinal J, et al.HMGB1:endogenousdanger signaling[J].Mol Med, 2008, 14 (7-8) :476-484. [33]Liu A, Jin H, Dirsch O, et al.Release of danger signal as amarker of organ quality during storage of liver:a potentialmarker of organ damage?[J].Mediators Inflamm, 2010:436145.Epub 2010 Dec 21. [33]Liu A, Jin H, Dirsch O, et al.Release of danger signal as amarker of organ quality during storage of liver:a potentialmarker of organ damage?[J].Mediators Inflamm, 2010:436145.Epub 2010 Dec 21. [34]Ilmakunnas M, Tukiainen EM, Rouhiainen A, et al.Highmobility group box 1 protein as a marker of hepatocellular in-jury in human liver transplantation[J].Liver Transpl, 2008, 14 (10) :1517-1525. [34]Ilmakunnas M, Tukiainen EM, Rouhiainen A, et al.Highmobility group box 1 protein as a marker of hepatocellular in-jury in human liver transplantation[J].Liver Transpl, 2008, 14 (10) :1517-1525. [35]Guo J, Friedman SL.Hepatic fibrogenesis[J].Semin LiverDis, 2007, 27 (4) :413-426. [35]Guo J, Friedman SL.Hepatic fibrogenesis[J].Semin LiverDis, 2007, 27 (4) :413-426. [36]Friedman SL.Hepatic fibrosis-overview[J].Toxicology, 2008, 254 (3) :120-129. [36]Friedman SL.Hepatic fibrosis-overview[J].Toxicology, 2008, 254 (3) :120-129. [37]Fehrenbach H, Weiskirchen R, Kasper M, et al.Up-regula-ted expression of the receptor for advanced glycation endproducts in cultured rat hepatc stellate cells during transdif-ferentiation to myofibroblasts[J].Hepatology, 2001, 34 (5) :943-952. [37]Fehrenbach H, Weiskirchen R, Kasper M, et al.Up-regula-ted expression of the receptor for advanced glycation endproducts in cultured rat hepatc stellate cells during transdif-ferentiation to myofibroblasts[J].Hepatology, 2001, 34 (5) :943-952. [38]Lohwasser C, Neureiter D, Popov Y, et al.Role of the re-ceptor for advanced glycation end products in hepatic fibrosis[J].WJG, 2009, 15 (46) :5789-5798. [38]Lohwasser C, Neureiter D, Popov Y, et al.Role of the re-ceptor for advanced glycation end products in hepatic fibrosis[J].WJG, 2009, 15 (46) :5789-5798. [39]Seki E, De Minicis S, Osterreicher CH, et al.TLR4 en-hances TGF-beta signaling and hepatic fibrosis[J].NatMed, 2007, 13 (11) :1324-1332. [39]Seki E, De Minicis S, Osterreicher CH, et al.TLR4 en-hances TGF-beta signaling and hepatic fibrosis[J].NatMed, 2007, 13 (11) :1324-1332. [40]Kao, Jawan B, Goto S, et al.High-mobility group box 1protein activates hepatic stellate cells in vitro[J].TransplProc, 2008, 40 (8) :2704-2705. [40]Kao, Jawan B, Goto S, et al.High-mobility group box 1protein activates hepatic stellate cells in vitro[J].TransplProc, 2008, 40 (8) :2704-2705.
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