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瘦素及其信号通路促肝纤维化机制研究进展

赵正斌 李俊峰 黄双盛 张立婷 陈红

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瘦素及其信号通路促肝纤维化机制研究进展

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  • 中图分类号: R575.2

The advances of profibrogenic research of leptin and its signaling pathways in hepatic fibrosis

  • 摘要: 多种慢性肝病能导致肝纤维化,肝纤维化是发展为肝硬化的中间阶段。肝星状细胞的激活在肝纤维化的发生发展中起关键作用。在各种炎症刺激下,体内促肝纤维化因子激活其信号转导通路,使肝星状细胞的形态和功能发生变化,引起胶原沉积。瘦素作为一种促肝纤维化因子,通过其信号转导机制在肝纤维化发生发展中发挥重要作用。

     

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  • 出版日期:  2011-10-20
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