PDF下载 ( 200 KB)
Clinical value of combined Alpha fetoprotein with C-reactive protein in the diagnosis of primary hepatic carcinoma
-
摘要: 目的通过对血清反应蛋白(CRP)与甲胎蛋白(AFP)联合检测,探讨其在原发性肝癌诊断与鉴别诊断中的价值。方法抽取52例临床确诊的原发性肝癌患者、68例肝硬化患者及50例健康体检者血液,化学发光免疫分析法检测CRP,放射免疫法检测AFP的浓度,以同期50例健康体检者作对照。结果原发性肝癌CRP、AFP水平与肝硬化及正常对照组比较差异均有统计学意义(P<0.05)。原发性肝癌组单项CRP、AFP阳性检出率分别为76.9%、73.1%;两项联合检测敏感度达94.2%,与AFP单项检测比较,差异有统计学意义(P<0.01)。结论联合检测CRP与AFP可提高原发性肝癌的检出率,对肝癌的诊断及鉴别诊断具有实用价值。Abstract: Objective To investigate the diagnostic and differential diagnosis value of combining CRP with AFP levels in primary hepatic carcinoma (PHC) .Methods Serum specimens of 52 PHC patients, 68 liver cirrhosis patients and 50 healthy controls were obtained.The CRP and AFP levels were tested by chemiluminescence immunoassay and RIA respectively.Results The serum concentration of CRP and AFP in PHC patients were significantly higher than those in liver cirrhosis patients and the control group.The positive rate of CRP and AFP in PHC group were 76.9%and 73.1% respectively.The sensitivity of combined detection was 94.2% in PHC group, which was significantly higher than that of single detection (P<0.01) .Conclusion Combined detection of AFP and CRP can increase the detection rate of hepatic carcinoma and it has practical value in diagnosing and differential diagnosis of hepatic carcinoma.
-
Key words:
- liver neoplasms /
- liver cirrhosis /
- alpha-fetoproteins /
- C-reactive protein
-
[1]彭莉, 朱传金.凝血四项与血清AFP的联合检测在肝癌患者中的临床应用及关系[J].肿瘤基础与临床, 2009, 22 (6) :519-520. [2]中华医学会.病毒性肝炎防治方案[J].中华内科杂志, 2001, 40 (1) :62-68. [3]中国抗癌协会肝癌专业委员会.原发性肝癌诊断标准[J].中华肝脏病杂志, 2000, 8 (3) :135. [4]信朝霞, 黄燕.恶性肿瘤患者急性时相反应蛋白测定及意义[J].河北北方学院学报 (医学版) , 2009, 26 (4) :51-53. [5]常炳庆, 黄家芳, 于洪远, 等.CRP定量检测异常在感染及肿瘤诊断中的意义[J].中国现代医药杂志, 2010, 12 (2) :54-55. [6]刘曼娇, 贺嘉蕾, 格日乐.C反应蛋白在肿瘤和感染性疾病中的临床应用价值[J].海军医学杂志, 2007, 28 (4) :305-307. [7]倪芳, 刘连科, 曾慧敏, 等.肿瘤复发患者化疗前后血清中CRP的变化[J].南京医科大学学报 (自然科学版) , 2007, 27 (10) :1143-1146. -
本文二维码
计量
- 文章访问数: 331
- HTML全文浏览量: 25
- PDF下载量: 124
- 被引次数: 0
下载:
