干细胞治疗在肝病中的应用

刘国旺; 曹武奎

干细胞治疗在肝病中的应用

天津市传染病医院

详细信息

中图分类号: R575
计量
- 文章访问数: 3535
- HTML全文浏览量: 21
- PDF下载量: 704
- 被引次数: 0
出版历程
- 出版日期: 2011-09-20

Application of stem cells in liver disease treatment

摘要

摘要: 近年来,干细胞治疗肝病受到广泛重视。在急性肝衰竭、终末期慢性肝病、遗传代谢性肝病等均有应用。干细胞有强大的自我更新能力。可分为肝细胞来源的干细胞和非肝细胞来源的干细胞。干细胞可向肝细胞或类肝细胞分化。
- 肝疾病 /
- 干细胞
Abstract: In recent years, stem cell therapy is widely applied in liver diseases, including acute liver failure, later-stage chronic liver disease, genetic metabolic liver disease and other liver diseases. Stem cells are strongly capable of self-renewal. Normally, stem cells originate from liver cells and non-liver cells, and they also can differentiate into hepatocyte cells and hepatocyte-like cells.
- liver diseases /
- stem cells

HTML全文

参考文献(25)

[1]Park IH, Zhao R, West JA, et al.Reprogramming of humansomatic cells to pluripotency with defined factors[J].Na-ture, 2008, 451 (7175) :141-146.

[2]Vogel G.Nobel Prizes a knock out award in medicine[J].Science, 2007, 318 (5848) :178-179.

[3]Takahashi K, Tanabe K, Ohnuk IM, et al.Induction of pluri-potent stem cell lines derived from human fibroblasts by de-fined factors[J].Cell, 2007, 131 (5) :861-872.

[4]Gaudio E, Carpino G, Cardinale V.New insights into liver stemcells[J].Digestive Liver Dis, 2009, 41 (7) :455-462.

[5]Wang P, Cong M, Liu TH, et al.Primary isolated hepatic ovalcells maintain progenitor cell phenotypes after two-year pro-longed cultivation[J].J Hepatol, 2010, 53 (5) :863-871.

[6]Lin CS, Xin ZC, Deng CH, et al.Defining adipose tissue-derived stem cells in tissue and in culture[J].Histol His-topathol, 2010, 25 (6) :807-815.

[7]Hay DC, Zhao D, Ross A, et al.Direct differentiation of humanembryonic stem cells to hepatocyte-like cells exhibiting func-tional activities[J].Cloning Stem Cells, 2007, 9 (1) :51-62.

[8]Bernardo ME, Catelli F, Fibbe WE.Mesenchymal stromalcells[J].Ann NY Acad Sci, 2009, 1176:101-117.

[9]王晓萃, 蒋吉英, 吴金生, 等.胎肝滤液诱导骨髓间充质干细胞向肝细胞分化[J].解剖学报, 2009, 40 (6) :923-927.

[10]韩翠萍, 刘吉勇, 高蕾, 等.脐血间充质干细胞的体外扩增及向类肝细胞分化的实验研究[J].山东医药, 2010, 50 (7) :3-5.

[11]Moon YJ, Yoon HH, Lee MW, et al.Multipotent progenitorcells derived from human umbilical cord blood can differenti-ate into hepatocyte-like cells in a liver injury rat model[J].Transplant Proc, 2009, 41 (10) :4357-4360.

[12]Campard D, Lysy PA, Najimi M, et al.Native umbilicaI cordmatrix stem cells express hepatic markers and differentiateinto hepatocyte-like cells[J].Gastroenterology, 2008, 134 (3) :833-848.

[13]Banas A, Teratani T, Yamamote Y, et al.In vivo therapeuticpotential of human adipose tissue mesenchymal stem cellsafter transplantation into mice with liver injury[J].Stemcells, 2008, 26 (10) :2705-2712.

[14]Mark AL, Sun Z, Warren DS, et al.Stem cell mobilization islife saving in an animal model of acute liver failure[J].AnnSurg, 2010, 252 (4) :591-596.

[15]Sun c, Li DG, Chen Yw, et al.Transplantation of urokinase-type plasminogen activator gone-modified hone marrowderived liver stem cells reduces liver fibrosis in rats[J].JGene Med, 2008, 10 (8) :855-866.

[16]Pai M, Zacharoulis D, Milicevic MN, et al.Autologous infu-sion of expanded mobilized adult bone marrow-derivedCD34+cells into patients with alcoholic liver cirrhosis[J].Am J Gastroenterol, 2008, 103 (8) :1952-1958.

[17]Alison MR, Islam S, Lim S.Stem cells in liver regeneration, fibrosis and cancer:the good, the bad and the ugly[J].JPathol, 2009, 217 (2) :282-298.

[18]Khan AA, Shaik MV, Parveen N, et al.Human fetal liver-derived stem cell transplantation as supportive modality inthemanagement of end-stage decompensated liver cirrhosis[J].Cell Transplant, 2010, 19 (4) :409-418.

[19]Kuo TK, Hung SP, Chuang CH, et al.Stem cell therapy forliver disease:parameters governing the success of usingbone marrow mesenchymal stem cells[J].Gastroenterolo-gy, 2008, 134 (7) :2111-2121.

[20]Enns GM, Millan MT.Cell-based therapies for metabolic liverdisease[J].Mol Genet Metab, 2008, 95 (1-2) :3-10.

[21]Khan AA, Parveen N, Mahaboob VS, et al.Management ofHyperbilirubinemia in biliary atresia by hepatic progenitor celltransplantation through hepatic artery:a case report[J].Transplant Proc, 2008, 40 (4) :1153-1155.

[22]Aurich H, SgoddaM, Kaltwasser P, et al.Hepatocyte differ-entiation of mesenchymalstem cells from human adipose tis-sue in vitro promotes hepatic integration in vivo[J].Gut, 2009, 58 (4) :570-581.

[23]Mahgerefteh SY, Sosna J, Bogot N, et al.Radiologic ima-ging and intervention for gastrointestinal and hepatic compli-cations of hematopoietic stem cell transplantation[J].Radi-ology, 2011, 258 (3) :660-671.

[24]Teisseyre M, Teisseyre J, KalicinskiP, et al.Liver transplan-tation for severe hepatic graft-versus-host disease in twochildren after hematopoietic stem cell transplantation[J].Transplant Proc, 2010, 42 (10) :4608-4610.

[25]陈海鸥, 胡小宣, 刘洪娟, 等.脐血干细胞移植治疗肝硬化的疗效观察[J].中华肝脏病杂志, 2010, 18 (7) :537-538.

施引文献

资源附件(0)

访问统计