Abstract: Objective To investigate the therapeutical effections of ERCP (endoscopic retrograde cholangiopancreatography) and biliary drainage on treating a veriety of beingn and malignant diseases with extrahepatic cholestatic stagnation.Methods 139 patients with extrahepatic cholestatic stagnation could choose the following remedial measures: EST (endoscopic sphincterotomy) , EPBD (endoscopic papillar bladder dilatation) , ENBD (endoscopic nosobiliary drainage) , ERBD (endoscopic retrograde biliary drainage) , EBMSD (endoscopic biliary mental stent drainage) when they were ascertained the location and character of bile duct's stericture and obstruction by ERCP examination.Results 59 patients who having beingn bile duct stricture disease were treated by using EST, EPBD, ENBD and ERBD.These diseases were majorly involved in the common bile duct stone, cholangitis, bile duct and papillary stricture, and biliary complication after liver transplantation.Among the malignant bile duct stricture patients, 14 of them were given ENBD treatment, 6 of them were given ERBD treatment, the others were given EBMSD treatment, these diseases were mostly involved in pancreatic head carcinoma, cholangiocarcinoma, and ampullary carcinoma.Primary carcinoma of liver together with intrahepatic and hilar metastasis which oppessing bile duct was also included.All patients' liver functional indexes were declined obviously such as total bilirubin, direct bilirubin, and so on;After the twogroups were 10, 6 patients had a transient serum amylase increased.Conclusion For patients with extrahepatic cholestatic stagnation, the theraputical technique by ERCP isn't only safe and effective, but also plays positive actions in a certain degree on treating stericture and obstruction of bile duct resulted from benign and malignant abnormality.