肝病患者肠道屏障功能变化的研究进展

王波; 宋怀宇; 杨建荣

肝病患者肠道屏障功能变化的研究进展

广西壮族自治区人民医院消化科

基金项目:

广西壮族自治区卫生厅重点项目课题资助(重2008010)；

详细信息

中图分类号: R575
计量
- 文章访问数: 3535
- HTML全文浏览量: 16
- PDF下载量: 792
- 被引次数: 0
出版历程
- 出版日期: 2011-08-20

The progress on the researches of intestinal barrier function changing in patients with liver diseases

Research funding:

摘要

摘要: 肠粘膜屏障功能障碍是肠道微生态改变和肠内炎性物质相互作用的后果,可造成肠壁通透性增加,肠道细菌或其毒性代谢产物向肠外移位,从而导致肠源性内毒素血症。许多研究发现肠道屏障功能损害对疾病的发生、发展有明确的促进作用。近年来,肝病患者肠道屏障功能变化的研究也备受关注,本文拟就近年来国内外对此问题的研究作一综述。
- 肝疾病 /
- 肠
Abstract: Intestinal barrier dysfunction is the result of mutual-interaction of intestinal gut microflora changing and the inflammatory substances, which can cause the increase of intestinal permeability, leading to intestinal bacteria translocation or endotoxemia.Many studies found that the intestinal barrier dysfunction had played an important role in the process of disease occurrence and development.In recent years, the relationship between the intestinal barrier dysfunction and development of disease has attracted more attention.This review is intended to summarize the latest progress in this area.
- liver diseases /
- intestines

HTML全文

参考文献(37)

[1]Grootjans J, Thuijls G, Verdam F, et al.Non-invasive assessment ofbarrier integrity and function of the human gut[J].World J GastrointestSurg, 2010, 2 (3) :61-69.

[2]Iurii K, Fridrik K, Grisham MB.Gut-associated lymphoid tissue, T cell trafficking, and chronic intestinal inflammation[J].Ann N YAcad Sci, 2010, 1207 (1) :86-93.

[3]Francesca F, Silvio D.Intestinal microbiota in inflammatory boweldisease:Friend of foe?[J].World J Gastroenterol, 2011, 17 (5) :557-566.

[4]Elaine O, Petrof.Probiotics and gastrointestinal disease:clinical evi-dence and basic science[J].Antiinflamm Antiallergy Agents MedChem, 2009, 8 (3) :260-269.

[5]De Palma GD, Rega M, Masone S, et al.Mucosal abnormalities ofthe small bowel in patients with cirrhosis and portal hypertension:acapsule endoscopy study[J].Gastrointest Endosc, 2005, 62 (4) :529-34.

[6]Kalaitzakis E, Johansson JE, Bjarnason I, et al.Intestinal permea-bility in cirrhotic patients with and without ascites[J].Scand J Gas-troenterol, 2006, 41 (3) :326-330.

[7]Lee S, Son SC, Han MJ, et al.Increased intestinal macromolecularpermeability and urine nitrite excretion associated with liver cirrhosiswith ascites[J].World J Gastroenterol, 2008, 14 (24) :3884-3890.

[8]Ibri?im D, Cevikba?.U, Akyüz F, et al.Intestinal metaplasia inportal hypertensive gastropathy:a frequent pathology[J].Eur JGastroenterol Hepatol, 2008, 20 (9) :874-880.

[9]Palma P, Mihaljevic N, Hasenberg T, et al.Intestinal barrier dys-function in developing liver cirrhosis:An in vivo analysis of bacteri-al translocation[J].Hepatol Res, 2007, 37 (1) :6-12.

[10]Natarajan SK, Ramamoorthy P, Thomas S, et al.Intestinal mucosalalterations in rats with carbon tetrachloride-induced cirrhosis:changes in glycosylation and luminal bacteria[J].Hepatology, 2006, 43 (4) :837-846.

[11]赵灏, 李晓欧, 王佩, 等.病毒性肝炎后肝硬化患者肠道的通透性[J].中华传染病杂志, 2002, 20 (2) :105-107.

[12]黄宏春, 王秀敏, 王永亮, 等.肠粘膜通透性改变对肝硬化自发性细菌性腹膜炎的影响[J].胃肠病学和肝病学杂志, 2008, 17 (10) :852-853.

[13]李兰娟, 吴仲文, 马伟杭.慢性重型肝炎肠道菌群变化的研究[J].中华传染病杂志, 2001, 19 (6) :345-347.

[14] 宋怀宇, 姜春华, 杨建荣.慢性乙型肝炎重度患者肠道粘膜屏障功能的变化及其临床干预策略[J].中华肝脏病杂志, 2009, 17 (10) :754-758.

[15]宋怀宇, 姜春华, 杨建荣.重度慢性乙型肝炎患者肠粘膜通透性的变化及相关因素分析[J].山东医药杂志, 2010, 50 (25) :27-28.

[16]Kolios G, Valatas V, Kouroumails E.Role of Kupffer cells in thepathogenesis of liver disease[J].World J Gastrorenterol, 2006, 12 (46) :7413-7420.

[17]Rao RK, Seth A, Sheth P.Recent advances in alcoholic liver dis-ease I.Role of intostinal permeability and endotoxemia in alcoholicdisease[J].Am J Physiol Gastrointest Liver Physiol, 2004, 286 (6) :G881-884.

[18]韩继武.非酒精性脂肪肝与胰岛素抵抗[J].生物磁学, 2006, 6 (1) :74-78.

[19]Limin S, Masayuki F, Nanthakumar T, et al.Toll-like receptor sig-naling in small intestinal epithelium promotes B-cell recruitment andIgA production in lamina propria[J].Gastroenterology, 2008, 135 (2) :529-538.

[20]崔巍, 马力, 闻颖, 等.暴发性肝衰竭时肠上皮细胞间紧密连接蛋Occludi表达下降[J].世界华人消化杂志, 2006, 14 (31) :3008-3012.

[21]Tang QJ, Wang LM, Tao KZ, et al.Expression of polymeric immu-noglobulin receptor mRNA and protein in human paneth cells:pan-eth cells participate in acquire dimmunity[J].Am J Gastroenterol, 2006, 101 (7) :1625-1632.

[22]Secchi A, Ortanderl JM, Schmidt W, et al.Effect of endotoxemiaon hepatic portal and sinusoidal blood flow in rats[J].J SurgRes, 2000, 89 (1) :26-30.

[23]Hashimoto N, Ohyanagi H.Effect of acute portal hyper-tension ongut mucosa[J].Hepatogastroenterology, 2002, 49 (48) :1567-1570.

[24]Damink SW, Jalan R, Dejong CH.Interorgan ammonia trafficking inliver disease[J].Metab Brain Dis, 2009, 24 (1) :169-181.

[25]Kasravi FB, Wang L, Wang XD, et al.Bacterial translocation in a-cute liver injury induced by D-galactosamine[J].Hepatology, 1996, 23 (1) :97-103.

[26]Parlesak A, Schafer C, Schutz T, et al.Increased intestinal perme-ability to macromolecules and endotoxemia in patients with chronicalcohol abuse in different stages of alcohol-induced liver disease[J].J Hepatol, 2000, 32 (5) :742-747.

[27]刘长安, 龚建平, 吴传新, 等.内毒素血症时小肠粘膜损害的实验研究[J].中华胃肠外科杂志, 2002, 5 (2) :149-152.

[28]Suzuki K, Meek B.Doi Y, et al.Aberrant expansion of segamentedfilamentous bacteria in IgA-deficient gut[J].Proc Natl Acad SciUSA, 2004, 101 (7) :1981-1986.

[29]Li S, Wu W C, He C Y, et al.Change of intestinal mucosa barrierfunction in the progress of non-alcoholic steatohepatitis in rats[J].World J Gastroenterol, 2008, 14 (20) :3254-3258.

[30]Adams DH, Eksteen B, Curbishley SM.Immunology of the gut andliver:a love/hate relationship[J].Gut, 2008, 57 (6) :838-848.

[31]Chokshi NK, Guner YS, Huntre CJ, et al.The role of nitric oxidein intestinal epithelial injury and restitution in neonatal necrotizingenterocolitis[J].Semin Perinatol, 2008, 32 (2) :92-99.

[32]Nakshabendi IM.Downie S, Russell RI, et al.Small intestinal mu-cosal protein synthesis and whole-body protein turnover in alcohol-ic liver disease[J].Clin Sci (Lond) , 1999, 97 (6) :633-638.

[33]Sanchez E, Casafont F, Guerra A, et al.Role of intestinal bacterialovergrowth and intestinal motility in bacterial translocation in experi-mental cirrhosis[J].Rev Esp Enferm Dig, 2005, 97 (11) :805-814.

[34]Albillos A, Hera AD, Ade L, et al.Tumour necrosis factor-alpha ex-pression by activated monocytes and altered T-cell homeostasis in as-citic alcoholic cirrhosis:amelioration with norfloxacin[J].J Hepatol, 2004, 40 (4) :624-631.

[35]Bode C, Bode JC.Activation of the innate immune system and alco-holic liver disease:effects of ethanol per se or enhanced intestinaltranslocation of bacterial toxins induced by ethanol?[J].AlcoholClin Exp Res, 2005, 29 (11) :166S-171S.

[36]宋红丽, 吕飒, 刘沛.暴发性肝衰竭小鼠肠粘膜上皮细胞凋亡的研究[J].中国医科大学学报, 2005, 34 (3) :223-224.

[37]Wu CC, Lu YZ, Wu LL, et al.Role of myosin light chain kinase inintestinal epithelial barrier defects in a rat model of bowel obstruc-tion[J].BMC Gastroenterol, 2010, 10 (1) :39.

施引文献

资源附件(0)

访问统计