Kupffer细胞在非酒精性脂肪性肝病发病机制中的作用

张利利; 向晓星

Kupffer细胞在非酒精性脂肪性肝病发病机制中的作用

苏北人民医院消化科

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中图分类号: R575.5
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出版历程
- 出版日期: 2011-08-20

Role of Kupffer cell in pathogenesis of nonalcoholic fatty liver disease

摘要

摘要: Kupffer细胞是肝脏的非实质细胞,具有分泌细胞因子及吞噬、免疫等功能,并与多种肝脏疾病如肝损伤、肝纤维化、肝硬化等密切相关。近年来,国内外学者对其在非酒精性脂肪性肝病(NAFLD)发生机制中的作用给予高度重视。本文从脂质代谢、信号蛋白变化、活性氧、抗原递呈等方面对Kupffer细胞在NAFLD发病机制中的作用进行综述。
- 脂肪肝 /
- 枯否细胞
Abstract: Kupffer cell is a kind of hepatic non-parenchymal cells, which possess functions of cytokine-secreting, phagocytosis, immunization, et al, and is closely related to many kinds of liver diseases such as liver injury, liver fibrosis, cirrhosis.More and more attentions have been given to the roles of kupffer cell on the pathogenesis of nonalcoholic liver disease (NAFLD) recently.This article reviews the lipid metabolism, changes of signal proteins, reactive oxygen, antigen-presenting of Kupffer cell in NAFLD.
- fatty liver /
- Kupffer cells

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参考文献(24)

[1]Petta, S.Muratore, C.Craxi, A.Non-alcoholic fatty liver dis-ease pathogenesis:The present and the future[J].Dig Liver Dis.2009, 41 (9) :615-625.

[2]Farrell GC, Teoh NC, McCuskey RS.Hepatic microcirculation infatty liver disease[J].Anat Rec (Hoboken) , 2008, 291 (6) :684-692.

[3]Kim JK.Fat uses a TOLL-road to connect inflammation and diabe-tes[J].Cell Metab, 2006, 4 (6) :417-419.

[4]Lee JY, Hwang DH.The modulation of inflammatory gene expres-sion by lipids:mediation through Toll-like receptors[J].MolCells, 2006, 21 (2) :174-185.

[5]Maher JJ, Leon P.Beyond insulin resistance:innate immunity innonalcoholic steatohepatitis[J].Hepatology, 2008, 48 (2) :670-678.

[6]Shi H, Kokoeva MV, Inouye K.TLR4 links innate immunity andfatty acid-induced insulin resistance[J].J Clin Invest, 2006, 116 (11) :3015-3025.

[7]Wouters K, Van Gorp PJ, Bieqhs V, et al.Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyper-lipidemic mouse models of nonalcoholic steatohepatitis[J].Hepa-tology, 2008, 48 (2) :474-486.

[8]Shiri-Sverdlov R.Early diet-induced non-alcoholic steatohepatitisin APOE2 knock-in mice and its prevention by fibrates[J].J Hepa-tol, 2006, 44 (4) :741.

[9]Larrouy D.Kupffer cells are a dominant site of uncoupling protein 2expression in rat liver[J].Biochem Biophys Res Commun, 1998, 235 (3) :760-764.

[10]Lee FY.Phenotypic abnormalities in macrophages from leptin-de-ficient obese mice[J].Am J Physiol, 1999, 276 (2 Pt 1) :C386-394.

[11]Fulop P, Derdak Z.Lack of UCP2 reduces Fas-mediated liver in-jury in ob/ob mice and reveals importance of cell-specificUCP2expression[J].Hepatology, 2006, 44 (3) :592-601.

[12]Ryu JW.Overexpression of uncoupling protein 2 in THP1 monocytesinhibits beta2 integrin-mediated firm adhesion and transendotheli-al migration[J].Arterioscler Thromb Vasc Biol, 2004, 24 (5) :864-870.

[13]Bai Y, Onuma H.Persistent NF-kappa B activation in Ucp2-/-mice leads to enhanced nitric oxide and inflammatory cytokineproduction[J].J Biol Chem, 2005, 280 (19) :19062-19069.

[14]Zhou M, Xu A.Mitochondrial dysfunction contributes to the in-creased vulnerabilitiesof adiponectin knockout mice to liver injury[J].Hepatology, 2008, 48 (4) :1087-1096.

[15]Musso G, Gambino R, Cassader M.Recent insights into hepaticlipid metabolism in non-alcoholic fatty liver disease (NAFLD) [J].Prog Lipid Res, 2009, 48 (1) :1-26.

[16]Stienstra, R.Saudale, F.Duval, C.et al.Kup?er cells promotehepatic steatosis via interleukin-1β-dependent sup-pressionof peroxisome proliferator-activated receptorαactivity[J].Hepatology, 2010, 51 (2) :511-522.

[17]Odegaard JI, Ricardo-Gonzalez RR.Macrophage-specificPPARgamma controls alternative activation and improves in-sulin resistance[J].Nature, 2007, 447 (7148) :1116-1120.

[18]Fuentes L, Roszer T, Ricote M.In flammatory mediators andinsulin resistance in obesity:role of nuclear receptor signalingin macrophages[J].Mediators of In flammation, 2010, 21 (9) :583.

[19]Marathe C, Bradley MN, Hong C, et al.Preserved glucosetolerance in high-fat-fed C57BL/6 mice transplantedwith PPARgamma-/-, PPARdelta-/-, PPARgammadelta-/-, or LXRalphabeta-/-bone marrow[J].J Lipid Res, 2009, 50 (2) :214-224.

[20]Adams LA, Lindor KD.Nonalcoholic fatty liver disease[J].Ann Epidemiol, 2007, 17 (11) :863-869.

[21]Zhan YT, Wei A.Roles of liver innate immune cells in nonal-coholic fatty liver disease[J].World J Gastroenterol, 2010, 16 (37) :4652-4660.

[22]Maher JJ, Leon P, Ryan JC.Beyond insulin resistance:In-nate immunity in nonalcoholic steatohepatitis[J].Hepatolo-gy, 2008, 48 (2) :670-678.

[23]Luckey SW, Petersen DR.Metabolism of 4-hydroxynonenalby rat Kupffer cells[J].Arch Biochem Biophys, 2001, 389 (1) :77-83.

[24]陆智杰.氟烷性肝炎免疫应答中Kupffer细胞的抗原递呈作用和MHC限制[J].第二军医大学学报, 2002, 23 (6) :112-114.

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