PDF下载 ( 163 KB)
Omeprazole combined with sucralfate on the prevention of upper gastrointestinal rebleeding in the cirrhosis with hepatitis B
-
摘要: 目的观察奥美拉唑联合硫糖铝持续口服预防乙型肝炎肝硬化患者上消化道再出血的临床疗效。方法将62例首次发生上消化道出血的乙型肝炎肝硬化患者分为预防组和对照组,预防组32例用奥美拉唑和硫糖铝持续口服,对照组30例未持续用药预防,时间为12个月。两组分别统计12个月内再出血总人次、住院总人次、再出血病例数和住院病例数。结果 12个月内预防组再出血总人次(平均人次)和住院总人次(平均人次)均明显低于对照组;预防组再出血病例数和住院病例数也明显低于对照组(P<0.001)。结论奥美拉唑联合硫糖铝持续口服预防乙型肝炎肝硬化患者上消化道再出血有较好的效果。Abstract: Objective To study the effect of continuous treatment with oral omeprazole combined with sucralfate in preventing upper gastrointestinal rebleeding in liver cirrhosis with hepatitis B.Methods Sixty two patients who had upper gastrointestinal hemorrhage were divided into prevention group and control group.Thirty two patients of prevention group took oral omeprazole combined with sucralfate for 12 months, while the patients in control group didn't take the medicine.The number of patients who had upper gastrointestinal hemorrhage and rebleeding, and the number of inpatients in the two groups were compared.Results The number of patients who had reoccurence of upper gastrointestinal hemorrhage and the number of inpatients in prevention group were lower than that of in control group after 12 months (P<0.001) .Conclusion Omeprazole combined with sucralfate is an effective method to prevent upper gastrointestinal rebleeding in liver cirrhosis with hepatitis B.
-
Key words:
- liver cirrhosis /
- hepatitis B /
- upper gastrointestinal hemorrhage /
- omeprazole /
- sucralfate
-
[1]中华医学会.慢性乙型肝炎防治指南[J].临床肝胆病杂志, 2006, 22 (1) :3-15. [2]孙剑经, 逯海, 高会斌, 等.胃镜检查肝硬化合并上消化道出血的临床研究[J].中国实用医药, 2008, 3 (35) :20-21. [3]Sorbi D, Gostout CJ, Peura D, et al.An assessment of the manage-ment of acute bleeding varices:a multicenter prospective member-based study[J].Am J Gastroenterol, 2003, 98 (11) :2424-2434. [4]李霞, 陈东风.肝炎后肝硬化非曲张静脉破裂出血98例分析[J].重庆医学, 2003, 32 (6) :752. [5]于皆平, 沈志祥, 罗和生.实用消化病学[M].第二版.北京:科学出版社, 2007:760-761. [6]Zaman A, Hapke R, Flora K, et al.Prevalence of upper and lowergastrointestinal tract findings in liver transplant candidates undergo-ing screening endoscopic evaluation[J].Am J Gastroenterol, 1999, 94 (4) :895-899. [7]李珍, 胡晋红, 邹多武.静脉滴注奥美拉唑药代动力学和24h动态pH监测[J].中国临床药理学杂志, 2000, 16 (4) :286-288. [8] 于皆平, 沈志祥, 罗和生.实用消化病学[M].第二版.北京:科学出版社, 2007:259-262. [9]Klinkenberg-Knol EC, Nelis F, Dent J, et al.long-term ome-prazole treatment in resistant gastroe-sophageal reflux disease:ef-ficacy, safety, and influence on gastric mucosa[J].Gastroenterolo-gy, 2000, 118 (4) :661-669. [10]Nagashima R.Mechanisms of action of sucralfate[J].Clin Gastro-enterol, 1981, 31 (Suppl 2) :117-127. [11]沙梅菊.奥美拉唑联合硫糖铝治疗消化性溃疡的疗效观察[J].中国社区医师, 2010, 12 (5) :64. [12]刘丽娜, 房文红.奥美拉唑与硫糖铝联合治疗慢性胃炎和消化性溃疡42例疗效观察[J].山西医药杂志, 2008, 37 (9) :814-815. -
本文二维码
计量
- 文章访问数: 1721
- HTML全文浏览量: 189
- PDF下载量: 149
- 被引次数: 0
下载:
