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肝癌循环肿瘤细胞的研究现状

陈洪 王智 吴健

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肝癌循环肿瘤细胞的研究现状

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  • 中图分类号: R735.7

Circulating tumor cells of hepatocellular carcinoma and their clinical implications

  • 摘要: 在原发性肝癌的早期阶段,癌细胞就可侵入血管、形成远处转移,致使患者失去有效治疗机会、预后不良。如果在转移性病灶形成之前能够在血液中发现循环肿瘤细胞(CTC),则可早期发现转移倾向。因而,能否有效地检测出肝癌CTC对判断治疗效果乃至阻断转移发生均有重要价值。目前用于检测肝癌CTC的分子标记物(如EpCAM、AFP等)在肝癌干细胞(CSC)也有表达,而且肝癌CTC在血液中数量极少,所以发现更加特异、敏感的CTC分子标记物以及开发更加高效的CTC检测技术对于提高肝癌CTC的临床应用价值具有重要意义。

     

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  • 出版日期:  2011-08-20
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