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铁超载与肝细胞癌关系的研究进展

赵睿 张岭漪

引用本文:
Citation:

铁超载与肝细胞癌关系的研究进展

基金项目: 

甘肃省自然科学基金(1010RJZA087); 

详细信息
  • 中图分类号: R735.7

Recent progress in relationship between iron overload and hepatocellular carcinoma

Research funding: 

 

  • 摘要: 肝细胞癌(HCC)的发生与多种因素有关。早期的流行病学研究显示非洲人群饮食中铁过量与HCC发生相关,继而研究发现许多与铁沉积相关的疾病如遗传性血色素沉积症(HH)、丙型病毒性肝炎、非酒精性脂肪性肝病(NAFLD)等在发展过程中均有发生HCC的可能性,提示铁超载可能在其中发挥着直接或间接的作用。现认为铁超载的发生与基因突变、铁代谢相关基因蛋白的异常表达、氧化应激反应、免疫紊乱、促进癌细胞生长等因素有关。本文就铁超载与HCC的相关研究现状作一综述。

     

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  • 出版日期:  2011-06-20
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