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Clinical analysis of primary biliary cirrhosis combined with diabetes mellitus
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摘要: 目的探讨原发性胆汁性肝硬化（PBC）患者合并糖尿病（DM）的发生率及临床特征。方法对2000年1月至2010年7月期间我院诊治的81例PBC患者的临床资料进行回顾性分析。比较PBC合并DM患者（DM组）与PBC无合并DM患者（非DM组）的一般资料、临床表现、并发症、合并症、肝功能指标、免疫学指标、胃镜表现等特征。结果 PBC患者合并DM的发生率为19.6%。DM组有双下肢水肿体征、腹水及胸水并发症的比例高于非DM组（43.8%vs 15.4%,P=0.03;75.0%vs 30.8%,P=0.001;25%vs 3.1%,P=0.01）。DM组抗线粒体抗体-M2水平为（91.3±65.7）Ru/ml,显著低于非DM组抗线粒体抗体-M2水平（171.1±84.0）Ru/ml（P=0.03）。两组肝功能指标等差异无统计学意义。结论 PBC合并DM患者临床表现不典型,PBC患者应定期监测血糖,及时诊治DM。Abstract: Objective To explore the incidence and clinical feature of primary biliary cirrhosis (PBC) combined with diabetes mellitus (DM) .Methods Clinical data of 81 cases of PBC were analyzed retrospectively in our hospital between Jan.2000 and Jul.2010.The clinical features, complications, liver function index, immunologica1 features and gastroscope performance was compared between the group of PBC combined with DM (DM group) and group of PBC without DM (non-DM group) .Results The incidence of PBC combined with DM was 19.6%.The proportion of patients with leg edema, ascites and hydrothorax complications was obviously higher in DM group than in non-DM group (43.8% vs 15.4%, P=0.03;75.0% vs 30.8%, P=0.001;25% vs 25%, P=0.01) .The anti-mitochondrial antibody M2 level was (91.3±65.7) Ru/ml in DM group, significantly lower than that in the non-DM group (171.1±84.0) Ru/ml, P=0.03.While there was no significant difference in liver function index between the two groups.Conclusion As the clinical manifestations were not typical, it is important for PBC patients combined with DM to monitor the blood sugar, timely diagnose and manage diabetes.
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Key words:
- liver cirrhosis /
- biliary
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