97例慢性乙型肝炎病毒感染者临床诊断和肝组织病理特征的关系

倪伟; 施维群

97例慢性乙型肝炎病毒感染者临床诊断和肝组织病理特征的关系

倪伟,
施维群

浙江中医药大学第二附属医院肝病科

基金项目:

国家“十一五”科技重大专项(2008ZX10005-008)；

详细信息

中图分类号: R512.62
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出版历程
- 出版日期: 2011-06-20

Clinical diagnosis and liver biopsy diagnosis of 97 cases with chronic HBV infection

Ni Wei,
Shi WeiQun

Research funding:

摘要

摘要: 目的总结分析慢性HBV感染者临床诊断与肝组织病理特征之间的关系,以期对临床诊断及治疗提供依据。方法对97例慢性HBV感染者(慢性HBV携带、慢性乙型肝炎)进行临床诊断分析及肝穿刺活检病理诊断、免疫组化检查。结果 55例慢性HBV携带者中S0～4分别为31、21、2、1、0例,分别占56.3%、38.1%、3.6%、1.8%、0.0%;G0～4分别为28、23、3、1、0例,分别占50.9%、41.8%、5.5%、1.8%、0.0%;30～40岁年龄段肝组织炎症及纤维化程度均高于其他两组。97例临床血清检测诊断为HBV感染者肝组织活检免疫组化结果有6例HBsAg阴性,7例HBcAg阴性。结论临床诊断为慢性HBV携带者及慢性肝炎轻度患者常常存在不同程度的肝脏炎症和纤维化,需要积极的干预治疗。肝组织活检病理诊断为临床诊疗提供巨大帮助,但也有一定局限性。
- 肝炎,乙型,慢性 /
- 肝炎病毒,乙型 /
- 活组织检查
Abstract: Objective To investigate the relationship between clinical and liver pathological characteristics in patients infected with hepatitis B virus (HBV) and to provide a reliable basis for the clinical diagnosis and treatment of chronic hepatitis B.Methods 97 cases of patients with chronic HBV infection (chronic HBV carriers/ chronic hepatitis B) were collected.Analysis of clinical diagnosis, liver biopsy diagnosis and immunohistochemical test were performed in all cases.Results 55 cases of chronic HBV carriers showed different degrees of inflammation (G) or fibrosis (S) : S0 56.3%, S1 38.1%, S2 3.6%, S4 0%, G0 50.9%, G1 41.8%, G2 5.5%, G3 1.8%, G4 0%.The degree of liver inflammation and fibrosis in patients of 30-40 age group was sever than the other two groups.HBsAg was negative in 6 patients with chronic HBV infection and HBcAg was negative in 7 patients with chronic hepatitis HBV infection by immunohistochemical test.Conclusion chronic HBV carriers and patients with mild chronic hepatitis different degrees of liver inflammation and fibrosis was observed in and active intervention.Pathologic diagnosis by liver biopsy diagnosis provides significant help for clinical diagnosis and treatment, but there are certain limitations.
- hepatitis B /
- chronic /
- hepatitis B virus

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参考文献(6)

[1]中华医学会.病毒性肝炎防治方案[J].中华肝脏病杂志, 2000, 8 (6) :324-329.

[2]程红春, 孙丽, 刘鹏, 等.肝穿刺活检术4449例临床分析[J].解放军医学杂志, 2005, 30 (4) :319.

[3]Lai M, Hyatt BJ, Nasser I, et al.The clinical significance of persistently normal ALT in chronic hepatitis B infection[J].Hepatology, 2007, 47 (6) :760-767.

[4]龙辉, 罗红涛, 赖春颜, 等.丙氨酸氨基转移酶低水平慢性乙型肝炎患者的肝脏病理分析[J].广东医学, 2008, 22 (10) :1672-1674.

[5]张玉果, 南月敏.慢性乙型肝炎临床与病理的对比分析[J].国际消化病杂志, 2007, 15 (6) :468-469.

[6] 施维群, 倪伟.60例肝病患者肝组织活检和临床诊断分析[J].中华临床感染病杂志, 2008, 1 (4) :227-228.

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