慢性乙型肝炎合并肝脂肪变的临床病理学特点及相关因素分析

邹志强; 强春倩; 李艳芳; 刘友德; 郎振为

慢性乙型肝炎合并肝脂肪变的临床病理学特点及相关因素分析

烟台市传染病医院

详细信息

中图分类号: R512.62
计量
- 文章访问数: 3751
- HTML全文浏览量: 7
- PDF下载量: 872
- 被引次数: 0
出版历程
- 出版日期: 2011-06-20

The clinical features and related factors of chronic hepatitis B with hepatic steatosis

摘要

摘要: 目的探讨慢性乙型肝炎(CHB)合并脂肪肝的临床病理学特征及相关因素。方法病例选自2008年7月~2009年12月期间有肝活组织检查的CHB患者306例,根据肝组织中脂肪变肝细胞<5%小叶内肝细胞者为CHB组,脂肪变肝细胞>5%者,为CHB合并脂肪肝组。对两组的临床与病理特征进行比较。结果 306例CHB患者中,合并肝脂肪变141例(46.1%),不合并肝脂肪变165例(53.9%)。各种临床生化及病理指标中,高体重指数(P<0.0001)和性别(P=0.008)是CHB患者合并肝细胞脂肪变的危险因素,与患者年龄、血糖、胆固醇和肝组织学炎症分级和分期无关(P>0.05)。结论 CHB合并肝脂肪变的发生主要与高体重指数及男性相关。
- 肝炎,乙型,慢性 /
- 脂肪肝 /
- 人体质量指数
Abstract: Objective To study the clinic-pathological characteristics and related factors in the patients of chronic hepatitis B with hepatic steatosis.Methods A total of 306 cases of chronic hepatitis B were chosen for this study, and divided into two groups according to the percentage of hepatic steatosis less than 5% or more than 5%.The two groups were compared regarding the presence of risk factors for steatosis and clinical laboratory, virological and histological characteristics.Results Among 306 chronic hepatitis B patients, there were 141 cases with steatosis (46.1%) and 165 cases without steatosis (53.9%) , respectively.High body mass index (BMI) and sex were independent factors and significantly higher in steatosis group than that in the group without steatosis (P<0.0001 and P=0.008, respectively) .No significant difference were found in the other parameters between two groups, including age, blood sugar, cholesterol, viral load, histological activity (HAI) and stage (P>0.05) .Conclusion The risk factors mainly related to steatosis were high body mass index and sex in chronic hepatitis B with steatosis.
- hepatitis B /
- chronic /
- fatty liver

HTML全文

参考文献(16)

[1]Williams R.Global challenges in liver disease[J].Hepatology, 2006, 44 (3) :521-526.

[2]Fan JG, Farrell GC.Epidemiology of non-alcoholic fatty liver disease in China[J].J Hepatol, 2009, 50 (1) :204-210.

[3] 中华医学会.慢性乙型肝炎防治指南[J].中华肝脏病学杂志, 2005, 13 (12) :881-891.

[4]Altlparmak E, Koklu S, Yallnklllc M, et al.Viral and host causes of fatty liver in chronic hepatitis B[J].World J Gastroenterol, 2005, 11 (20) :3056-3059.

[5]王家祥, 刘英棣.脂肪肝的影像学诊断[J].肝脏, 2001, 6 (3) :194-195.

[6] 张继平.临床内科学[M].天津:科技出版社, 1999:1888.

[7]范建高, 朱军, 李新建, 等.上海市成人脂肪肝患病率及其危险因素流行病学调查[J].中华肝脏病学杂志, 2005, 13 (2) :83-88.

[8]Fan JG, Chitturi S.Hepatitis B and fatty liver:causal or coincidental[J].Gastroenrol Hepatol, 2008, 23 (5) :679-681.

[9] 宓余强, 刘永刚, 徐亮, 等.慢乙肝合并肝脂肪变的临床与病理学特征分析[J].中华肝脏病学杂志, 2009, 17 (11) :817-819.

[10]Shi JP, Fan JG, Wu R, et al.Prevalence and risk factors of hepatic steatosis and its impact on liver injury in Chinese patients with chronic hepatitis infection[J].Gastroenterol Hapatol, 2008, 23 (9) :1419-1425.

[11]Peng D, Han Y, Ding H, et al.Hepatic steatosis in chronic hepatitis B patients is associated with metabolic factors more than viral factors[J].J Gastroenterol Hepatol, 2008, 23 (7 Pt 1) :1082-1088.

[12]魏永梅.慢性乙型肝炎重叠非酒精性脂肪肝肝病56例临床分析[J].肝脏, 2005, 10 (1) :68-69.

[13]Chu CM, Lin DY, Liaw YF.Does increased body mass index with hepatic steatosis contribute to seroclearance of hepatitis B virus (HBV) surface antigen in chronic HBV infection[J].International J Obesity, 2007, 31 (5) :871-875.

[14]Liew PL, Lee WJ, Lee YC, et al.Hepatic histopathology of morbid obesity:concurrence of other forms of chronic liver disease[J].Obes Surg, 2006, 16 (12) :1584-1593.

[15]Prati D, Taioli E, Zanella A, et al.Updated definitions of healthy ranges for serum alanine aminotransferase levels[J].Ann lntern Med, 2002, 137 (1) :1-10.

[16]Kariv R, Leshno M, Beth-Or A, et al.Re-evaluation of serum alanine aminotransferase upper normal limit and its modulating factors in a large-scale population study[J].Liver Int, 2006, 26 (4) :445-450.

施引文献

资源附件(0)

访问统计