原发性胆汁性肝硬化与弥漫结缔组织病的肝损伤

张奉春

原发性胆汁性肝硬化与弥漫结缔组织病的肝损伤

张奉春

中国医学科学院北京协和医院风湿免疫科

详细信息

中图分类号: R575.2
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出版历程
- 收稿日期: 2011-01-25
- 出版日期: 2011-06-20

Primary biliary cirrhosis and liver disease secondary to diffuse connective tissue diseases

Zhang FengChun

摘要

摘要: 自身免疫性肝病是一组以肝脏为靶器官的自身免疫疾病,弥漫性结缔组织病的肝损伤是一组肝器官特异性的自身免疫病,越来越多的研究发现这两组疾病无论在临床表现以及基础免疫学的免疫异常变化都有相互联系。本文着重分析了弥漫性结缔与原发性胆汁性肝硬化的相关性,包括它们之间重叠存在的比例、临床症状、自身抗体的相关性,以及病理和免疫学的差异,目的就是希望提高对原发性胆汁性肝硬化(PBC)及弥漫性结缔组织病(CTD)肝损伤的认识,进一步深入研究,提高诊断和治疗水平。
- 肝硬化,胆汁性 /
- 结缔组织疾病 /
- 肝疾病 /
- 自身免疫疾病
Abstract: Autoimmune liver disease comprises of a group of liver-targeting autoimmune diseases, whereas diffuse connective tissue disease (DCTD) is a group of non-organ-specific autoimmune diseases.Increasing evidences have suggested that these two groups of disorders are closely related, not only by their clinical manifestations but also their basic immunological mechanisms.This paper focuses on correlation between DCTD and primary biliary cirrhosis (PBC) , including their overlapping rate, clinical symptoms, autoantibody profile as well as their pathological and immunological differences, so as to update our knowledge of PBC and liver disease secondary to DCTD, and promote more profound investigation to improve our diagnosis and treatment of these disorders.
- liver cirrhosis /
- biliary /
- connective tissue diseases /
- liver diseases

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参考文献(13)

[1]Watt FE, James OF, Jones DE.Patterns of autoimmunity in primary biliary cirrhosis patients and their families:a population-based cohort study[J].QJM, 2004, 97 (7) :397-406.

[2]Bach N, Odin JA.Primary biliary cirrhosis:a mount sinai perspective[J].Mt Sinai J Med, 2003, 70 (4) :242-250.

[3]Marasini B, Gagetta M, Rossi V, et al.Rheumatic disorders and primary biliary cirrhosis:an appraisal of 170 Italian patients[J].Ann Rheum Dis, 2001, 60 (11) :1046-1049.

[4]Kaplan MJ, Wike R.The liver is a common non-exocrine target in primary sjgren's syndrome:a retrospective review[J].BMC Gastroenterology, 2002, 2:21.

[5]Lindgren S, Manthorpe R, Eriksson S.Autoimmune liver disease in patients with primary sjgren's syndrome[J].J Hepatol, 1994, 20 (3) :354-358.

[6]Talwalkar JA, Lindor KD.Primary biliary cirrhosis[J].Lancet, 2003, 362 (9377) :53-61.

[7]Hansen BU, Lindgren S, Eriksson S, et al.Clinical and immunological features of Sjgren's syndrome in patients with primary biliary cirrhosis with emphasis on focal sialadenitis[J].Acta Med Scand, 1988, 224 (6) :611-619.

[8]张烜, 唐福林, 李永哲, 等.原发性胆汁性肝硬化的临床及病理分析[J].中华风湿病学杂志, 2001, 5 (2) :598-601.

[9]Matsumoto T, Morizane T, Aoki Y, et al.Autoimmune hepatitis in primary Sjgren's syndrome:pathological study of the livers and labial salivary glands in 17 patients with primary Sjgren's syndrome[J].Pathology International, 2005, 55 (2) :70-76.

[10]尤欣, 刘炜, 张烜, 等.原发性胆汁性肝硬化和原发性干燥综合征患者血清中不同抗核抗体型别的分析[J].中华医学杂志, 2008, 88 (3) :168-170.

[11]史旭华, 张奉春, 张烜.抗着丝点抗体在原发性胆汁性肝硬化中的意义[J].中华风湿病学杂志, 2006, 10 (8) :485-487.

[12]蒋明, David Yu, 林孝义, 等.中华风湿病学[M].北京:华夏出版社, 2004:583-589.

[13]Abraham S, Begum S, Isenberg D.Hepatic manifestations of auto-immune rheumatic diseases[J].Ann Rheum Dis, 2004, 63 (2) :123-129.

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