基于蛋白质组学筛选获得的乙型肝炎病毒相关肝癌诊断标志物的研究进展

张丽军; 贾小芳; 滕珍林; 程能能

基于蛋白质组学筛选获得的乙型肝炎病毒相关肝癌诊断标志物的研究进展

1. 复旦大学药学院药理学系
2. 上海市公共卫生临床中心

基金项目:

上海市自然科学基金(09ZR1426300)；国家863课题资助项目(2006AA02A411)；

详细信息

中图分类号: R735.7
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出版历程
- 出版日期: 2011-05-20

Biomarkers of liver cancer related to hepatitis B virus selected by proteomics

Research funding:

摘要

摘要: 肝癌是世界上死亡率最高的恶性肿瘤之一,乙型肝炎病毒(HBV)是主要的致病原,然而,HBV感染相关的肝癌发病机制不明,早期诊断非常困难。蛋白质组学为肝癌研究开辟了新的途径,受到研究者的关注。本文对近3年在HBV相关肝癌发病机制、肝癌标志物筛选研究方法及已发现的肝癌诊断标志物方面取得的研究成果进行了综述。
- 肝炎病毒,乙型 /
- 肝肿瘤 /
- 肿瘤标记,生物学 /
- 蛋白质组学
Abstract: Hepatocellular carcinoma (HCC) is one of the most deadly malignancies worldwide.Hepatitis B virus (HBV) is widely recognized as one of the major etiological factors of HCC.However, the mechanism of liver cancer related to HBV infection is still unclear.Liver cancer is difficult to detect in an early stage.Proteomics has caused researcher's wide attention due to its complementary to other research methods in liver cancer study.Herein, we review the latest three year developments in the studies of proteomics applied to liver cancer related to HBV infection, to summarize the diagnosis biomarkers and cancerization mechanism of liver cancer related to HBV infection.
- hepatitis B virus /
- liver neoplasms /
- tumor markers /
- biological

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参考文献(40)

[1]Cabibbo G, Craxi A.Epidemiology, risk factors and surveillance of hepatocellular carcinoma[J].Eur Rev Med Pharmacol Sci, 2010, 14 (4) :352-355.

[2]Lopez JB.Recent developments in the first detection of hepatocellular carcinoma[J].Clin Biochem Rev, 2005, 26 (3) :65-79.

[3]Gomaa AI, Khan SA, Leen EL, et al.Diagnosis of hepatocellular carcinoma[J].World J Gastroenterol, 2009, 15 (11) :1301-1314.

[4]Chen X, Jorgenson E, Cheung ST.New tools for functional genomic analysis[J].Drug Discov Today, 2009, 14 (15-16) :754-760.

[5]Rousseau D, Khochbin S, Gorka C, et al.Induction of H1 (0) -gene expression in B16 murine melanoma cells[J].Eur J Biochem, 1992, 208 (3) :775-779.

[6]Baltimore D.Our genome unveiled[J].Nature, 2001, 409 (6822) :814-816.

[7]Zhang L, Peng X, Zhang Z, et al.Subcellular proteome analysis unraveled annexin A2 related to immune liver fibrosis[J].J Cell Biochem, 2010, 110 (1) :219-228.

[8]Saito Y, Oba N, Nishinakagawa S, et al.Identification of beta2-microgloblin as a candidate for early diagnosis of imaging-invisible hepatocellular carcinoma in patient with liver cirrhosis[J].Oncol Rep, 2010, 23 (5) :1325-1330.

[9]Li WH, Miao XH, Qi ZT, et al.Proteomic analysis of differently expressed proteins in human hepatocellular carcinoma cell lines HepG2 with transfecting hepatitis B virus X gene[J].Chin Med J (Engl) , 2009, 122 (1) :15-23.

[10]Lee NP, Chen L, Lin MC, et al.Proteomic expression signature distinguishes cancerous and nonmalignant tissues in hepatocellular carcinoma[J].J Proteome Res, 2009, 8 (3) :1293-1303.

[11] Zubaidah RM, Tan GS, Tan SB, et al.2-D DIGE profiling of hepatocellular carcinoma tissues identified isoforms of far upstream binding protein (FUBP) as novel candidates in liver临床肝胆病杂志2011年第27卷第5期carcinogenesis[J].Proteomics, 2008, 8 (23-24) :5086-5096.

[12]Tong A, Wu L, Lin Q, et al.Proteomic analysis of cellular protein alterations using a hepatitis B virus-producing cellular model[J].Proteomics, 2008, 8 (10) :2012-2023.

[13]Li N, Long Y, Fan X, et al.Proteomic analysis of differentially expressed proteins in hepatitis B virus-related hepatocellular carcinoma tissues[J].J Exp Clin Cancer Res, 2009, 28 (1) :122.

[14]Steel LF, Shumpert D, Trotter M, et al.A strategy for the comparative analysis of serum proteomes for the discovery of biomarkers for hepatocellular carcinoma[J].Proteomics, 2003, 3 (5) :601-609.

[15]Sun S, Lee NP, Poon RT, et al.Oncoproteomics of hepatocellular carcinoma:from cancer markers'discovery to functional pathways[J].Liver Int, 2007, 27 (8) :1021-1038.

[16]Lee A, Chick JM, Kolarich D, et al.Liver membrane proteome glycosylation changes in mice bearing an extra-hepatic tumour[J].Mol Cell Proteomics, 2010.

[17]Wilson B, Liotta LA, Petricoin E, 3rd.Monitoring proteins and protein networks using reverse phase protein arrays[J].Dis Markers, 2010, 28 (4) :225-232.

[18]Tao SC, Chen CS, Zhu H.Applications of protein microarray technology[J].Comb Chem High Throughput Screen, 2007, 10 (8) :706-718.

[19]Kim S, Lee D.Mining metastasis related genes by primary-secondary tumor comparisons from large-scale databases[J].BMC Bioinformatics, 2009, 10 (Suppl 3) :S2.

[20]Sun W, Zhong F, Zhi L, et al.Systematic-omics analysis of HBV-associated liver diseases[J].Cancer Lett, 2009, 286 (1) :89-95.

[21]Block TM.Use of targeted glycoproteomics to identify serum glycoproteins that correlate with liver cancer in woodchucks and humans[J].Proceedings of the National Academy of Sciences, 2005, 102 (3) :779-784.

[22]Feng JT, Liu YK, Song HY, et al.Heat-shock protein 27:a potential biomarker for hepatocellular carcinoma identified by serum proteome analysis[J].Proteomics, 2005, 5 (17) :4581-4588.

[23]Lim SO, Park SJ, Kim W, et al.Proteome analysis of hepatocellular carcinoma[J].Biochem Biophys Res Commun, 2002, 291 (4) :1031-1037.

[24]Sun S, Poon RT, Lee NP, et al.Proteomics of hepatocellular carcinoma:serum vimentin as a surrogate marker for small tumors (

[25]Na K, Lee EY, Lee HJ, et al.Human plasma carboxylesterase 1, a novel serologic biomarker candidate for hepatocellular carcinoma[J].Proteomics, 2009, 9 (16) :3989-3999.

[26]Yeo M, Na YM, Kim DK, et al.The loss of phenol sulfotransferase 1 in hepatocellular carcinogenesis[J].Proteomics, 2010, 10 (2) :266-276.

[27]Ren F, Wu H, Lei Y, et al.Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma[J].Mol Cancer, 2010, 9 (1) :81.

[28]Wu L, Peng CW, Hou JX, et al.Coronin-1C is a novel biomarker for hepatocellular carcinoma invasive progression identified by proteomics analysis and clinical validation[J].J Exp Clin Cancer Res, 2010, 29 (1) :17.

[29]Bin-sheng F, Wei L, Jian-wen Z, et al.Serum proteomic analysis on metastasis-associated proteins of hepatocellular carcinoma[J].J South Med Univ, 2009, 29 (9) :1775-1779.

[30]Shu H, Kang X, Guo K, et al.Diagnostic value of serum haptoglobin protein as hepatocellular carcinoma candidate marker complementary to alpha fetoprotein[J].Oncol Rep, 2010, 24 (5) :1271-1276.

[31]Long J, Lang ZW, Wang HG, et al.Glutamine synthetase as an early marker for hepatocellular carcinoma based on proteomic analysis of resected small hepatocellular carcinomas[J].Hepatobiliary Pancreat Dis Int, 2010, 9 (3) :296-305.

[32]Yang F, Yin Y, Wang F, et al.An altered pattern of liver apolipoprotein A-I isoforms is implicated in male chronic hepatitis B progression[J].J Proteome Res, 2010, 9 (1) :134-143.

[33]Huang Q, Wang L, Bai S, et al.Global proteome analysis of hepatitis B virus expressing human hepatoblastoma cell line HepG2[J].J Med Virol, 2009, 81 (9) :1539-1550.

[34]Ma Y, Yu J, Chan HL, et al.Glucose-regulated protein 78 is an intracellular antiviral factor against hepatitis B virus[J].Mol Cell Proteomics, 2009, 8 (11) :2582-2594.

[35]Feng H, Wang M, Chen WN.iTRAQ-coupled 2D LC-MS/MS analysis of secreted proteome of HBV-replicating HepG2 cells:potential in biomarkers for prognosis of HCC[J].Curr Microbiol, 2010, 61 (4) :280-284.

[36]Feng H, Li X, Niu D, et al.Protein profile in HBx transfected cells:a comparative iTRAQ-coupled 2D LC-MS/MS analysis[J].J Proteomics, 2010, 73 (8) :1421-1432.

[37]Niu D, Sui J, Zhang J, et al.iTRAQ-coupled 2-D LC-MS/MS analysis of protein profile associated with HBV-modulated DNA methylation[J].Proteomics, 2009, 9 (15) :3856-3868.

[38]Zhang J, Niu D, Sui J, et al.Protein profile in hepatitis B virus replicating rat primary hepatocytes and HepG2 cells by iTRAQ-coupled 2-D LC-MS/MS analysis:Insights on liver angiogenesis[J].Proteomics, 2009, 9 (10) :2836-2845.

[39]Wang X, Zhou Y, Sun L, et al.Complex Formation between Heat Shock Protein 72 and Hepatitis B Virus X Protein in Hepatocellular Carcinoma Tissues[J].J Proteome Res, 2008, 7 (12) :5133-5137.

[40]Kim SY, Lee PY, Shin HJ, et al.Proteomic analysis of liver tissue from HBx-transgenic mice at early stages of hepatocarcinogenesis[J].Proteomics, 2009, 9 (22) :5056-5066.

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