非酒精性脂肪性肝病患者肝脏声辐射力脉冲成像的临床观察

张大鹍; 赵媛媛; 李志艳; 陈敏; 刘阳; 谢跃; 董晓宇; 周艳贤; 苏颖

非酒精性脂肪性肝病患者肝脏声辐射力脉冲成像的临床观察

1. 解放军第三0二医院超声科
2. 青岛市市立医院超声科

基金项目:

首都医学发展科研基金资助项目(2009-3059)；

详细信息

中图分类号: R575.5
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出版历程
- 出版日期: 2011-05-20

The initial study of quantitative evaluation of the degree of non-alcoholic fatty liver disease by acoustic radiation force impulse imaging

Research funding:

摘要

摘要: 目的探讨声辐射力脉冲成像(ARFI)技术评价非酒精性脂肪性肝病(NAFLD)患者肝脏弹性的临床价值。方法分别对76例NAFLD患者和30例健康对照者应用声辐射力脉冲成像技术进行肝脏弹性的检测,比较并分析各组间肝脏弹性定量参数的差异。结果 NAFLD组与对照组间ARFI测值差异具有统计学意义(P<0.01),NAFLD不同程度组间ARFI测值差异具有统计学意义(P<0.01),重度与轻、中度组比较,差异具有统计学意义(P<0.01)。随NAFLD患者脂肪肝程度的加重,肝脏的ARFI测值也逐渐增高,两者存在正相关(r=0.453,P<0.01)。结论声辐射力脉冲成像技术不仅无创,更可较准确的对NAFLD患者肝脏弹性进行定量评价。
- 脂肪肝 /
- 弹性成像技术
Abstract: Objective To investigate the clinical value of the acoustic radiation force impulse (ARFI) technique in the quantitative evaluation of non-alcoholic fatty liver disease.Methods 76 patients with non-alcoholic fatty liver disease and 30 normal healthy controls were examined using acoustic radiation force Impulse technique.Results The parameter of ARFI in non-alcoholic fatty liver disease group was significantly lower than that in the control group (P<0.01) .In non-alcoholic fatty liver disease patients, there were significant differences in the parameter of ARFI among the mild, moderate and severe fatty liver groups (P<0.01) .The difference in ARFI between the severe group and other two groups was significant (P<0.01) .A positive correlation was found between the stiffness of the liver and the sonography grade of fatty liver (r=0.453, P<0.01) .The ARFI parameter of the liver increased along with an increase in the degree of fatty liver.Conclusion Acoustic radiation force impulse technique not only can examine the stiffness of the liver noninvasively, but also has potential value for quantitative evaluation of the degree of non-alcoholic fatty liver disease.
- fatty liver /
- elastography imaging techniques

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参考文献(10)

[1]中华医学会.非酒精性脂肪性肝病诊疗指南[J].中华肝脏病杂志, 2006, 14 (3) :161-163.

[2]Clark JM, Brancati FL, Diehl AM.Nonalcoholic fatty liver disease[J].Gastroenterology, 2002, 122:1649-1657.

[3]Hepburn MJ, Vos JA, Fillman EP, et al.The accuracy of the report of hepatic steatosis on ultrasonography in patients infected with hepatitis C in a clinical setting:A retrospective observational study[J].BMC Gastroenterology, 2005, 13 (5) :14.

[4]Ophir J, Céspedes I, Ponnekanti H, et al.Elastography:a quantitative method for imaging the elasticity of biological tissues[J].Ultrason Imaging, 1991, 13 (2) :111-134.

[5]Asteria C, Giovanardi A, Pizzocaro A, et al.US-elastography in the differential diagnosis of benign and malignant thyroid nodules[J].Thyroid, 2008, 18 (5) :523-531.

[6]Shao J, Bai J, Cui L, et al.Elastographic evulation of the temporal formation of ethanol-induced hepatic lesions[J].J Ultrasound Med, 2007, 26 (9) :1191-1199.

[7]Takahashi H, Ono N, Eguchi Y, et al.Evaluation of acoustic radiation force impulse elastography for fibrosis staging of chronic liver disease:a pilot study[J].Liver Int, 2010, 30 (4) :538-545.

[8]Fierbinteanu-Braticevici C, Andronescu D, Usvat R, et al.Acoustic radiation force imaging sonoelastography for noninvasive staging of liver fibrosis[J].World J Gastroenterol, 2009, 15 (44) :5525-5532.

[9]郭瑞军, 南月敏, 王明花等.家免脂肪肝肝压缩率、灰阶强度与声衰减对比研究[J].中国医学影像技术, 2004, 20 (8) :1186-1189.

[10]Sandrin L, Fourquet B, Hasquenoph JM, et al.Transient elastography:a new noninvasive method for assessment of hepatic fibrosis[J].Ultrasound Med Biol, 2003, 29 (12) :1705-1713.

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