苦参碱联合干扰素α-2b治疗转氨酶轻度升高慢性乙型肝炎患者的疗效观察

王旭; 袁成民; 吴谙诏; 鹿勇; 赵玉娟

苦参碱联合干扰素α-2b治疗转氨酶轻度升高慢性乙型肝炎患者的疗效观察

1. 菏泽医学专科学校
2. 济南市传染病医院

基金项目:

山东省教育厅科技发展计划项目(J07YE13)；

详细信息

中图分类号: R512.62
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出版历程
- 出版日期: 2011-05-20

The observation of anti-viral effect of matrine combined with interferon α-2b on the chronic hepatitis B patients with mild transaminase elevations

Research funding:

摘要

摘要: 目的观察注射用苦参碱联合重组人干扰素α-2b对转氨酶轻度升高慢性乙型肝炎（CHB）患者的抗病毒疗效,并从细胞免疫学角度探讨其作用机制。方法研究对象为随机选择CHB轻度患者60例,苦参碱联合重组人干扰素α-2b组及重组人干扰素α-2b组各30例,观察治疗1个月ALT、AST及治疗3个月HBeAg定量、HBV DNA载量变化;同时采用流式细胞技术检测外周血淋巴细胞各亚群数量。结果治疗3个月HBV DNA载量、HBeAg定量显著降低,CD3+T、CD4+T和CD8+T细胞计数均显著升高,两组比较差异有统计学意义（P<0.01）。结论苦参碱联合重组人干扰素α-2b对于CHB转氨酶轻度升高的患者有较好的抗病毒疗效和安全性。
- 肝炎,乙型,慢性 /
- 干扰素α-2b /
- 苦参碱
Abstract: Objective To observe anti-viral effect of matrine combined with interferon α-2b on the chronic hepatitis B patients with mild transaminase elevations and study the mechanism of cellular immunology.Methods 60 cases of mild chronic hepatitis B were randomly divided into two groups: the group of matrine combined with recombinant human interferon α-2b and the monotherapy group of recombinant human interferon α-2b.The change of ALT, AST after one month of treatment, and titers of HBeAg and the load of HBV DNA after three months of treatment were detected respectively.In addition, the quantity of subpopulation of peripheral blood lymphocyte were also detected by flow cytometry.Results After the treatment, the titers of HBeAg and the load of HBV DNA significantly decreased and CD3+T, CD4+ and CD8+T significantly increased.There is obvious difference between the two groups (P<0.01) .Conclusion Matrine combined with recombinant human interferon α-2b has better anti-viral effect and is more safer for chronic hepatitis B patients with mild transaminase elevations.
- hepatitis B /
- chronic /
- interferon alfa-2b

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参考文献(8)

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