Abstract: Objective To observe the intervention mechanism of Qinggantiaozhi decoction on non-alcoholic steatohepatitis insulin resistance (IR) by animal experiment.Methods The model of NASH was established by feeding Wistar rats with high fat diet and were randomly divided into 4 groups.The groups of Qinggantiaozhi decoction in low dose, middle dose and high dose, and the control group of silybin, were treated by corresponding medicine.After 12 weeks, all the rats were put to death.The serum TG, TC, GLu, Leptin, FFA, INS were detected.The liver tissue was stained by both fat and glycogen.All the above positive results were analyzed by quantitative analysis.Results After analyzing the experimental data, all the above indexes are improved in the treated groups compare with those of in model group (P<0.05, P<0.01) .The index of TG, GLu, FFA, INS is reduced in high dose group of Qinggantiaozhi decoction than that in silybin group (P<0.05) .Conclusion There maybe several mechanisms for Qinggantiaozhi decoction to prevent and cure NASH.The most important one is to correct disordered blood-fat and reduce the deposition of fat in hepatic cell through improving the resistance of insulin and leptin, promoting metabolism of FFA and TG in hepatic cell.It demonstrates that the Qinggantiaozhi decoction can obviously reduce the blood-fat and improve the iconography appearance of the nonalcoholic steatohepatitis.